摘要
特应性皮炎是一种慢性复发性、瘙痒性、炎症性皮肤病，该病发病机制不清，涉及遗传、免疫、感染等多种因素。近年来发现浸润到皮损局部的T细胞，其产生的细胞因子在该病的发生发展过程中起着重要作用，尤其是新发现有四个螺旋结构的细胞因子白介素-31。它主要由Th2细胞产生，与特应性皮炎瘙痒的发生有密切联系。
Atopic dermatitis represents a pruritic, chronic, relapsing inflammatory skin disease. Its pathogenesis remains unclear, and may be associated with genetic, immunologic and infective factors. Recently, a series of experiments have confirmed that cytokines released by T cells infiltrating in local lesional skin play an important role in the development of atopic dermatitis. For example, interleukin-31, a newly identified four-helix bundle cytokine preferentially produced by T helper type 2 cells, is closely related to the development of pruritus in atopic dermatitis.
出处
《国际皮肤性病学杂志》
2008年第3期164-166,共3页
International Journal of Dermatology and Venereology
