摘要
IL-21是于2000年发现的属于IL-2细胞因子家族的新成员。它同该家族其它成员（IL-2、IL-4、IL-7、IL-9、IL-13和IL-15）共用一个受体亚单位γc。IL-21由活化的CD4^＋T辅助细胞产生的，其受体表达在多种免疫细胞（B、T、NK细胞）上，因此对多种免疫细胞有重要的生物调节作用。IL-21能提高B淋巴细胞的增殖，提高IgG1的产生，抑制IgE的产生，从而调节人体体液免疫。IL-21还可增强NK细胞、T淋巴细胞的增殖与杀伤功能，从而增强人体的细胞免疫。作为最新的免疫系统调节因子，IL-21在免疫调节、抗肿瘤中的作用越来越受到研究者的重视，已成为该领域的研究热点。
Interleukin 21 （ IL-21 ） , a member of Interleukin 2 （IL-2） cytokine family, was discovered in 2000. It shares a common subunit of γc with the other members （such as IL-2,IL-4,IL-7, IL-9,IL-13 and IL-15 ） of the IL-2 cytokine family. IL-21 is produced by activated CD4 positive cells, and its receptor is expressed on many immune cells, such as B lymphocytes, T lymphocytes and NK cells. Therefore, IL-21 has an important regulated effect on the immune cells. It can promote the proliferation of B lymphocytes, enhance the producti6n of IgG1, inhibit the production of IgE, and regulate the cellular immunity. In addition, IL-21 can also promote the proliferation and enhance the function of both NK cells and T lymphocytes. Therefore, IL-21 regulates humoral immunity. As an immune regular, IL-21 plays an important role in the immne regulation and anti-tumor immunotherapy, and has gained a great deal of interest in the related researches.
出处
《国际免疫学杂志》
CAS
2008年第5期360-364,共5页
International Journal of Immunology
基金
天津市卫生局科技基金（05KY10）和教育部留学归国人员科研启动基金（教外司留[2007]1108号）
