摘要
目的研究ApoE e4等位基因与全麻苏醒期躁动(EA)之间的关系。方法选择年龄≥60岁的全麻下择期腹部手术患者,在麻醉恢复室采用Riker镇静、躁动评分(Sedation-Agitation Scale,SAS)进行躁动诊断,并采用PCR-RFLP方法进行ApoE基因型测定。结果共有196例患者入选本研究,其中39例(22.4%)发生了EA;38例(19.4%)携带ApoE e4等位基因。e4等位基因、低水平教育程度分别是EA发生的危险因素(36.9%vs 15.8%,P=0.005,30%vs 14.3%,P=0.01)。多因素回归分析显示e4等位基因与EA有关联(odds ratio:4.32,95%CI:1.75～10.05)。结论ApoE e4等位基因是发生EA的高危因素。
Objective To investigate the relationship between apolipoprotein e4 allele and emergence agitation （EA） in patients undergoing general anesthesia. Methords A nested cohort study was conducted in elderly patients （over 60 years old） scheduled for major abdominal surgery requiring general anesthesia. A structured interview was conducted in PACU to determine EA, defined using the Sedation-Agitation Scale （SAS）. Blood samples were obtained for measurement of the apolipoprotein genotypes. Results Of the 196 patients studied, 22.4% developed EA. Thirty-eight patients （19.4%） had the apolipoprotein e4 allele. The presence of the e4 allele and low level of education were both associated with an increased risk of EA （36.9% vs15.8%, P=-0.005; 30% vs 14.3%, P=-0.01）. After adjustment for covariates, the patients with the copy of e4 allele were shown to have a greater likeliness of an increased risk of EA （odds ratio： 4.32; 95% CI： 1.75-10.05） than those without the e4 allele. Conclusion Apolipoprotein e4 carrier status is associated with an increased risk for EA.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第9期1652-1653,共2页
Journal of Southern Medical University
基金
广东省医学科研基金(A2005555)
