摘要
目的:探讨神经元特异性烯醇化酶(neuron-specific-enolase,NSE)在缺氧缺血性脑病(HIE)新生儿血清中的变化,旨在评价高压氧治疗新生儿HIE的临床价值。方法:76例HIE患儿(包括32例轻度HIE,24例中度HIE,20例重度HIE)被平均分为高压氧组和常规治疗组,两组均于治疗前、治疗后10d进行NSE测定,另选10例健康儿作为正常儿组,亦进行NSE测定。NSE用放射免疫法进行测定。结果:治疗前NSE水平高压氧组(轻、中、重度)分别为(12.0±2.5)、(19.4±3.5)、(28.4±8.8)μg/L;常规治疗组(轻、中、重度)分别为(11.9±2.6)、(19.2±3.4)、(28.2±8.9)μg/L;正常儿组为(6.4±2.0)μg/L。治疗后NSE水平高压氧组(轻、中、重度)分别为(6.5±2.0)、(6.5±2.1)、(6.8±3.0)μg/L;常规治疗组(轻、中、重度)分别为(8.0±2.0)、(8.4±2.2)、(9.8±3.2)μg/L;正常儿组为(6.2±2.1)μg/L。不同程度HIE患儿治疗前NSE水平明显增高,与正常儿组比较差异有显著性(P<0.05)。治疗10d后不同程度HIE患儿NSE水平明显下降,与治疗前比较差异有显著性(P<0.05),且高压氧组下降得更为显著;高压氧组与常规治疗组比较,治疗前两者NSE水平差异无显著性(P>0.05),治疗后两组比较差异有显著性(P<0.05)。结论:常规治疗配合高压氧治疗可更有效改善HIE患儿血NSE水平,促使受损脑细胞尽快恢复。
Objective To monitor the changes of serum neuron-specific-enolase （NSE） level in neonates with hypoxic ischemic encephalopathy （HIE） before and after hyperbaric oxygen treatment （HBO）, so as to assess the applicating value of HBO in treating HIE. Methods Seventy-six neonates with HIE, including 32 cases of mild HIE, 24 cases of moderate HIE and 20 cases of severe HIE, were evaluated respectively. They were divided into group treated with HBO and group treated with routine treatment. The serum NSE levels of the two groups were measured before treatment and 10 clays after treatment. In addition, the health neonates were selected as the control group. The serum NSE levels of various groups were measured with radioimmunolgical methods. Results The NSE levels of neonates before treatment in HBO-treatment-group （mild, moderate and severe respectively） were （12.0 ± 2.5）, （19.4 ± 3.5） and （28.4 ± 8.8） μg/L; that in routine-treatment-group （mild, moderate and severe respectively） were （11.9 ± 2.6）, （19.2 ± 3.4） and （28.2 ± 8.9） μg/L; and in control group was （6.4 ± 2.0） μg/L. The NSE levels of neonates after 10 days＇ treatment in HBO-treatment-group （mild, moderate and severe respectively） were （6.5 ± 2.0）, （6.5 ± 2.1） and （6.8± 3.0） μg/L; that in routine-treatment-group （mild, moderate and severe respectively） were （8.0 ± 2.0）, （8.4 ± 2.2） and （9.8 ± 3.2）μg/L; and in control group was （6.2 ±2.1） μg/L. The NSE levels of HIE neonates significantly increased before treatment, and there were significant differences between HIE-baby and normal-baby groups （P 〈 0.05）. After ten days＇ treatment, the NSE levels of HIE neonates significantly decreased （P 〈 0.05）, and the changes of NSE levels in HBO-treatment-group were more notable. There were no significant （P 〉 0.05） differences of the NSE levels between HBO-treatment-group and routine-treatment-group before treatment, whereas, there were significant differences （P 〈 0.05） between them after ten days＇ treatment. Conclusion Routine treatment combined with hyperbaric oxygen treatment can more effectively ameliorte the NSE levels of neonates with HIE, and accelerate the recovery of damaged cerebral cells as soon as possible.
出处
《实用医学杂志》
CAS
2008年第18期3135-3137,共3页
The Journal of Practical Medicine
关键词
缺氧缺血
脑
婴儿
新生
高压氧
神经元特异性烯醇化酶
Hypoxia-ischemia, brain Infant, newborn Hyperbaric oxygenation Neuron-specific-enolase
