摘要
本文用双抗体夹心酶标记免疫分析法动态检测30例脑出血患者发病一周内(第1～7天)血浆中神经元特异性烯醇化酶(Neuron—specific enolase,NSE)的浓度。结果显示脑出血急性期内血浆 NSE 增高,发病一周内的平均 NSE 值及最大 NSE 值均与 CT 显示的脑血肿体积呈正相关。高 NSE 的患者病情重,预后不良;病情轻、预后良好者,NSE 仅轻度上升。但 NSE 升高不显著者,并不一定意味着病情轻、预后良好。动态检测 NSE 有助于监测患者病情的变化。
Plasma samples taken from 30 patients with cerebral hemorrhage were collected in the first 7 days after the onset and were determined with sandwich-type enzyme immunoassay using a kit for the measurement of NSE.Increased concentrations of NSE in Plasma were found in patients with cerebral hemorrhage during the first 7 days after the acute event.It showed the positive correla- tion between plasma mean/max NSE levels and volume of hematoma.There was only a mild increase of plasma NSE levels in cases who had a good recovery.High plasma NSE level indicated an un- favourable outcome and severe disease;But mild increase of NSE level did not permit a reliable estima- tion about the severity and prognosis of the diseeas.It suggested that repeated measurements of plas- ma NSE levels might be useful to follow the course of the dsease.
出处
《卒中与神经疾病》
1996年第2期90-92,共3页
Stroke and Nervous Diseases
关键词
脑出血
特异性烯醇化酶
血浆
Cerebral hemorrhage
Phosphopyruvate hydratase
