摘要
通过化学合成方法合成线性长度七肽分子CKGDWDC,进而通过在(1,7)位形成二硫键构成共价闭合环状结构,最终形成KGD环七肽.结构计算结果显示,KGD环七肽中的KGD序列表现出功能构象,具有较强的抗血小板聚集活性,能够专一性识别与结合血小板膜上纤原受体,具有较强的抑制血栓形成的能力.KGD环七肽具有较强的实际应用价值和广阔的应用前景.
A Linear hepta-peptide Cys-Lys-Gly-Asp-Trp-Asp-Cys was synthesized, with a disulfide bond subsequently formed between the Cysl and Cyst to obtain a cyclo-heptapeptide containing Lys-Gly-Asp. Structural simulation showed that the Lys-Gly-Asp sequence displayed functional conformation. This cycloheptapeptide exhibited potent platelet anti-aggregation activity, by specific recognition and interaction with the GP Ⅱb/Ⅲ a receptor. The peptide＇s specific and potent anti-thrombosis activity implicates that the cycloheptapeptide could be potentially used in the clinic.
出处
《北京师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2008年第4期417-419,共3页
Journal of Beijing Normal University(Natural Science)
基金
国家"十五"医药卫生青年基金资助项目(Z12044)
