摘要
对高血压病患者血浆血小板球蛋白、血栓烷B_2(TxB_2)及体外ADP诱导血小板聚集(PA)和生成TxB_2量测定,表明高血压病一期组仅PA明显增加,而二期组所有指标均显著增加。提示适当的抗血小板药物配合降压治疗对控制高血压病的发展及并发症的发生可能有益。
Paired study of platelet activities in 50-70 year old subjects with and without essential hypertensin is reported.1) patients with stage 2 hypertension had elevated plasma concentration of P-TG ad TXB2 as compared with the control (P <0.05) . 2) TxB2 generation of platelets in vitro induced by ADP was significantly increased both in the patients with stage 1(P <0.05) and stage 2 ( P >01) hypertension than the control . 3) A.trend of enhanced plasma concentration of P-TG, TxB2, PA and TxB2 synthesis in vitro in the patients withstage 1 hypertension were observed, but only the difference of plateler aggregation reached statistical significance. It is indicated that the platelet function in the hypertensive subjects is increased and coordinated with the development of the disease. Appropriate antiplatelet drug therepy in addition to anti-hypertensives is rational .
出处
《湖南医科大学学报》
CSCD
1990年第3期271-273,276,共4页
Bulletin of Hunan Medical University
关键词
高血压
血小板功能
hypertension
platelet aggreration
beta-thromboglobulin
thromboxane B2
