摘要
目的观察新风胶囊对活动期类风湿关节炎(RA)患者的疗效及对血小板参数、超微结构、P-选择素(CD62P)的影响。方法检测60例活动期RA患者血小板参数、CD62P及各活动性指标,并随机分为新风胶囊组35例和正清风痛宁组25例,治疗1个疗程后,观察2组疗效和上述各指标的变化。另设正常对照组20例并检测上述指标。其中每组2例采用透射电镜观察血小板超微结构。结果与正常对照组相比,活动期RA患者血小板计数(PLT)、血小板压积(PCT)、血小板平均体积(MPV)、CD62P显著升高,血小板超微结构破坏严重。新风胶囊组显效率显著高于正清风痛宁组。治疗后新风胶囊组及正清风痛宁组患者血小板超微结构明显改善,新风胶囊组改善更明显,且PLT、PCT、CD62P显著降低。PLT、PCT与CD62P、免疫球蛋白G、血沉、C反应蛋白、类风湿因子、关节疼痛、关节肿胀呈正相关关系,PLT还与关节压痛和晨僵时间呈正相关关系。结论活动期RA患者PLT、PCT显著升高,且与各活动性指标具有相关性,提示PLT、PCT可作为反映RA活动性的客观指标;新风胶囊能通过改善血小板超微结构从而减少CD62P释放来改善RA患者的关节炎症病变,延缓病情进展。
Objective To observe effects of Xinfeng capsule （XFC） on platelet parameters, ultrastructure, p-selectin and therapeutic effect on rheumatoid arthritis （RA） patients in active phase. Methods Platelet parameters, p-selectin and reactive indexes of 60 RA patients in active phase were detected. RA patients were divided into XFC treated group （35 examples） and Zhengqing Fengtongning （ZQF） control group （25 examples） randomly. After a course of treatment, the therapeutic effect and changes of platelet parameters, p-selectin, reactive indexes of two groups were observed. Setting up a normal control （20 examples） and detecting above-mentioned indexes. Observing platelet ultrastructure of two examples with transmission electron microscope of per groups. Results Compared with normal control group, PLT, PCT, MPV, CD62P of RA patients in active phase was obviously increased. Platelet ultrastructure was obviously damaged. The excellence rate of XFC exceeded ZQF control group. After being treated, platelet ultrastructure of the two groups were obviously improved, and XFC group was better than ZQF group. Compared with ZQF group, PLT, PCT, CD62P were obviously decreased in XFC group. PLT, PCT were positively correlated with CD62P, IgO, ESR, CRP, RF, arthrpain, arthrocele. And PLT was positively correlated with arthrtenderness, morning stiffness time. Conclusion PLT and PCT of RA patients in active phase were increased, and have correlation with reactive indexes. It suggests that PLT, PCT can reflect reactiveness of RA as objective indexes. XFC can not only treat inflammation and delay the aggravation of RA patient by improving platelet ultrastructure.
出处
《中国中医药信息杂志》
CAS
CSCD
2008年第9期5-7,11,共4页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家中医药管理局科研课题专项基金(04-05LP27)
安徽省十一五攻关项目(07010300204)
安徽科技重点研究项目(06023068)
