摘要
目的观察青蒿素配伍丝裂霉素(MMC)对肺癌细胞增殖作用的影响。方法采用四甲基偶氮唑蓝法(MTT法)分析青蒿素配伍MMC含药血清对体外培养肺癌细胞增殖的影响。结果青蒿素与MMC配伍使用,含药血清对体外培养的人肺癌细胞(A549)的抑制率为40.8%。结论青蒿素与MMC配伍使用可显著提高对A549细胞的杀伤作用,提示青蒿素和丝裂霉素配伍使用在肺癌治疗中具有很好的临床应用前景。
Objective To investigate the anti -tumor effect of artemisinin and mitomycin （MMC） on proliferation of lung cancer cells in vitro. Methods The eytotoxic effect of artemisinin and MMC sera on sarcoma A549 in mice were determined by MTT assay in vitro. Results The compatible use of artemisinin and MMC could obviously inhibit the growth of cultured A549 cells. Artemisinin serum could also inhibit A549 celts. The inlfibition rates were respectively 40.8% and 31.9% under the group that with artemisinin and MMC. Conclusion Artemisinin and MMC can inhibit the growth of A549 cells in vitro.
出处
《中国药业》
CAS
2008年第17期8-9,共2页
China Pharmaceuticals
