摘要
细胞凋亡时,细胞形态会发生一系列特征性的改变。近年来,发现细胞骨架也会发生相应的变化,包括细胞骨架网状结构降解、凝聚和分布不均等。通过对细胞骨架蛋白的生物活性、功能及细胞凋亡时细胞骨架结构形态的动态变化、相关调控因素等研究,显示凋亡细胞骨架改变是细胞凋亡形态学改变的基础,提示可通过改变细胞骨架结构来诱导细胞凋亡,以达到治疗肿瘤及其他疾病的目的。
During cell apoptosis, a series of characteristic changes occur in the cell configuration and, according to recent findings, in the cytoskeleton as well, including degradation, condensing and maldistribution of the cytoskeleton reticular formation. Through investigations of the biological activity and function of the cytoskeleton protein, the dynamic changes of the cytoskeleton during cell apoptosis and related regulatory factors, we found that the change of configuration is based on that of the cytoskeleton during cell apoptosis, which suggests that we can achieve the purpose of curing tumors and other diseases by inducing cell apoptosis through changing the cytoskeleton configuration.
出处
《医学研究生学报》
CAS
2008年第8期877-880,共4页
Journal of Medical Postgraduates
基金
南京军区医学科学技术研究"十一五"计划重点课题(批准号:06Z37)
