摘要
目的探讨后程三维适形放射治疗结合化疗治疗直肠癌术后复发的疗效。方法49例术后复发直肠癌随机分为适形放疗加化疗组（适形组）25例，常规放疗加化疗组（常规组）24例。适形组前程采用6MVX线全盆腔放疗46Gy后改作三维适形放射治疗推量至70Gy，常规组采用6MVX线全盆腔放疗46Oy；后采用两后斜野成角照射推量至66Gy，两组均于放疗第一周及最后一周化疗，予5-氟尿嘧啶500mg／m^2，甲酰四氢叶酸钙200mg，d1～5，静脉滴注。生存分析采用Kaplan-Meier法。结果适形组和常规组1、2、3年生存率分别为88．0％、64．0％、48．0％和66．7％、45．8％、37．5％（P=0．08），中住生存期分别为35和22月；3年肿瘤局部控制率分别为68．0％、41．7％（P〈0．05），毒副反应两组差异无统计学意义。结论三维适形放射治疗结合化疗是治疗直肠癌术后复发的有效治疗方法，能明显地提高患者的近期生存率。
Objective To evaluate the effects of the late course 3-dimensional conformal radiotherapy combined with chemotherapy for rectal cancer of postoperative local recurrence. Methods Forty-nine rectal cancer patients of postoperative local recurrence were divided randomly into two groups..25 cases received 3D-CRT plus chemotherapy（3D-CRT group）,24 cases received conventional radiotherapy plus chemotherapy（conventional group）. A total tumor doses of 46 Gy by the 6MVX beam to the all pelvic for conventional radiotherapy in the first course , followed in the 3D-CRT group by 3D-CRT to DT 70 Gy,in the conventional group by two field for conventional radiotherapy to 66 Gy. Two groups were all treated one course by 5-Flu plus CF in the first week, and the last week. Kaplan-Meier method was used for survival analysis. Results The 1,2, 3 years survival rates for 3D-CRT group and conventional group were 88. 0% ,64. 0%,48. 0% and 66.7%,45.8%,37. 5% （P = （k 08）. The 3 years local control rate for two group was 6B. 0%,41.7% （P〈0. 05）respectively. The median survival was 35 and 22 months respectively. The side effects were similar in the two groups. Conclusion 3-dimensional conformal radiotherapy combined with chemotherapy can be considered as an effective and feasible approach to rectal cancer patients of postoperative local recurrence, and may significantly improve the survival rate.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2008年第8期593-596,共4页
Cancer Research on Prevention and Treatment
关键词
直肠肿瘤
肿瘤复发
适形放疗
化疗
Rectal neoplasms Neoplasm recurrence Conformal Radiotherapy Chemotherapy
