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坎地沙坦酯的大鼠在体肠吸收研究 被引量：2

Intestinal absorption of Candesartan cilexetil in rats
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摘要 目的:考察坎地沙坦酯的大鼠在体肠吸收的情况。方法:采用大鼠在体单向灌流实验装置,分别考察坎地沙坦酯在大鼠不同肠段、不同浓度的坎地沙坦酯在大鼠空肠段以及坎地沙坦酯与其他药物共同作用在空肠段的吸收情况。结果:坎地沙坦酯在小肠各肠段(十二指肠、空肠、回肠)的吸收无显著性差异,在小肠内无明显的特定吸收部位。坎地沙坦酯的药物浓度改变对小肠吸收存在显著性差异;6种药物(环孢素,维拉帕米,乳酸,氢氯噻嗪,非诺贝特,硝苯地平)分别与坎地沙坦酯合用对坎地沙坦酯在小肠中的吸收无显著性影响。结论:坎地沙坦酯的小肠吸收不因为肠段不同而有区别;药物浓度对于坎地沙坦酯吸收影响较大;环孢素等药物对坎地沙坦酯的吸收无影响。
作者 张晶 薛亮
机构地区 第二军医大学长海医院药学部 上海市精神卫生中心
出处 《第二军医大学学报》 CAS CSCD 北大核心 2008年第8期994-996,共3页 Academic Journal of Second Military Medical University
关键词 坎地沙坦酯 在体单向灌流 肠吸收
分类号 R969 [医药卫生—药理学]
  • 相关文献

参考文献8

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二级参考文献14

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共引文献147

同被引文献19

  • 1赵燕强,杨立新,张宪民,邱明华.威灵仙的成分、药理活性和临床应用的研究进展[J].中药材,2008,31(3):465-470. 被引量：63
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二级引证文献16

第二军医大学学报
2008年 第8期

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