摘要
应用大鼠在体肠吸收实验方法研究了法莫替丁各肠段的吸收动力学特征。实验表明 :法莫替丁在肠道各部位的吸收速率按十二指肠、空肠、回肠、结肠顺序下降 ,吸收速率常数分别为0 0 5 0 8,0 0 44 6 ,0 0 415 ,0 0 2 87h-1。药物在肠道内的吸收呈现一级吸收动力学过程 。
To explore the absorption mechanism of famotidine from various intestinal segments, the absorption kinetics and permeability rate constants(ka) were investigated by the in situ perfusing method in rats. It was showed that the small intestine was the best absorption segment. The permeability rate constants were 0 050 8 , 0 044 6 , 0 041 5 , 0 028 7 h -1 respectively at duodenum, jejunum, ileum and colon. The absorption mechanism of famotidine was studied at different concentrations. No saturation phenomenon occurred and at the same time, ka was kept unchanged. The results indicated that the absorption of famotidine compiled with the passive transport mechanism and first order kinetics.
出处
《沈阳药科大学学报》
CAS
CSCD
2001年第3期170-172,共3页
Journal of Shenyang Pharmaceutical University
