摘要
目的：通过分析复方丹参注射液治疗新生儿窒息合并肾功能损害的疗效,探讨复方丹参注射液对新生儿窒息后肾损害的保护作用。方法：收集80例合并肾损害的新生儿窒息病例,分为丹参组及对照组,丹参组在支持、对症治疗基础上加用复方丹参注射液,足月儿4~6ml、早产儿2ml,加入10%葡萄糖注射液10ml静脉滴注,1日1次,自出生第3天~第10天用。比较两组患儿出生第3天、第10天尿量、BUN、Scr结果以及尿量恢复正常的日龄。结果：两组患儿第3天尿量、BUN、Scr值无统计学差异,两组患儿第10天较第3天尿量增加、BUN、Scr下降;丹参组第10天尿量（2.61±1.05）ml·kg-1·h-1、BUN（3.35±1.12）mmol/L、Scr（66.51±8.11）μmol/L,对照组第10天尿量（2.50±1.12）ml·kg-1·h-1、BUN（6.55±2.21）mmol/L、Scr（100.31±8.98）μmol/L,丹参组较对照组BUN、Scr下降（P〈0.01）;尿量恢复正常时间丹参组为3~7d,平均（5.02±1.00）d;对照组为5~10d,平均（7.12±2.11）d,两组比较有统计学差异（P〈0.01）。结论：新生儿窒息合并肾损害加用复方丹参注射液辅助治疗后,肾功能及尿量恢复正常时间早,提示复方丹参注射液对新生儿窒息肾损害可起到保护作用。
Objective：To explore the therapeutic effects of the complex Danshen Zhusheye to the renal dysfunction after neonatal asphyxia. Methods：To collect the clinical data of 80 cases of neonatal renal dysfunction after asphyxia and divide them into Danshen group and control group randomly. The complex Danshen Zhusheye was used in the Danshen group with the dose of 4ml to 6ml in term infants and 2 ml in preterm infants, intravenous drip,once per day, from day 3 after birth till day 10 after birth. The other treatments in two groups were similar. The urine outputs were recorded from the first day after birth till the day when urine outputs were normal. Blood urea nitrogen （BUN） and serum creatinine （Scr） were detected at day 3 and day 10. Results：The differences of urine outputs,BUN and Scr in two groups at day 3 were not significant. At day 10,compared with day 3, the urine outputs were increased and the BUN and Scr were decreased in both groups. The urine outputs were （2.61 ± 1.05） ml·kg^- 1·h^- 1 and （2.50 ± 1.12） ml·kg^- 1·h^- 1, BUN were （3.35 ± 1.12）mmol/L and （6.55 ± 2.21） mmol/L and Scr were （66.51 ± 8.11）mmol/L and （ 100.31 ± 8.98）μmol/L in Danshen group and control group respectively at day 10. Compared with the control group, the BUN and Ser were decreased in Danshen group with P〈 0.01 at day 10. The day that the urine outputs were normal was 5.02 ± 1.00 （3--7）d in Danshen group and 7.12 ± 2.11 （5-- 10）d in control group. The difference was highly significant with P〈 0.01. Conclusion：The recover time was earlier with Danshen treatment in neonatal renal dysfunction after asphyxia, which can hint that the complex Danshen Zhusheye is effective to protect the renal function after neonatal asphyxia.
出处
《中国中西医结合肾病杂志》
2008年第8期698-700,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
关键词
窒息
肾功能
丹参
新生儿
Asphyxia Renal function Danshen Newborn
