摘要
目的：观察中老年慢性肾脏病（CKD）患者骨密度变化,了解骨质疏松患病情况。方法：以305名中老年（年龄≥50岁）慢性肾脏病3~5期且尚未透析治疗患者为观察对象,102名非慢性肾脏病中老年志愿者为对照组。采用双能X线骨密度（DXA）仪测定腰椎正位（L1~4）和股骨等部位的骨密度（BMD）,观察CKD患者骨质疏松患病情况。按性别或CKD分期进行再分组,进一步观察不同性别或不同CKD分期条件下患者骨质疏松患病情况。结果：中老年慢性肾脏病患者总骨质疏松患病率为37.8%,男性组患病率为28.2%,女性组患病率49.2%,与对照组相比均有明显升高（P〈0.01或P〈0.05）。按CKD分期观察,随慢性肾衰竭程度加重,骨质疏松患病率逐渐增加,其中CKD5期患者与CKD3、CKD4期患者比较其骨质疏松患病率增加更加明显（P〈0.01或P〈0.05）。结论：中老年慢性肾脏病患者具有较高的骨质疏松患病率;随慢性肾衰竭程度加重,骨质疏松患病率有逐渐增加趋势;慢性肾衰竭是否为骨质疏松症的危险因素尚需探讨。
Objective：To analysis the bone mineral density （BMD） and the prevalence rate of osteoporosis in middleaged and elderly patients with chronic kidney disease. Methods：305 middle- aged and elderly patients with chronic kidney disease （CKD 3- 4 stage, aged over 50 years） were included and 102 peoples without CKD were set as control group. The bone mass density at the lumbar spine （L1-4 ） and femur was detected by dual energy. X- ray absorptiometry （DXA）. The prevalence rate of osteoporosis was analysed in total CKD patients and subgroups according to the sex and CKD stages. Results：The total prevalence rate of osteoporosis in CKD patients was 37.8 % ,of whom the rate of males was 28.2 % and that of females 49.2 %. There was very significant difference in prevalence rates between the CKD patient group and the control group （P 〈 0.01 or P 〈 0.05）. The prevalence rate of osteoporosis was increased with the decline of the renal function, especially in patients with severe CKD. There was much higher prevalence rate of osteoporosis in CKD 5 stage patients than that in CKD 3 or 4 stage patients（ P〈0.01 or P〈0.05）. Conclusion.There was higher prevalence rate of osteoporosis in middle - aged and elderly patients with chronic kidney disease. The prevalence rate of osteoporosis was increased with the decline of the renal function. Whether CKD is a risk factor for osteoporosis needs more research.
出处
《中国中西医结合肾病杂志》
2008年第8期687-690,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
关键词
慢性肾脏病
骨密度
骨质疏松
中老年
Chronic kidney disease Bone mineral density Osteoporosis Middle- aged
