摘要
目的:探讨细胞周期蛋白D1(Cyclin D1)与热休克蛋白70(hot shock protein70,HSP70)在肝细胞肝癌(HCC)中的表达及意义。方法:以石蜡包埋组织芯片为材料,分别检测145例HCC、78例肝硬化和16例来自尸检的正常肝组织标本的Cyclin D1和HSP70的表达。结果:Cyclin D1和HSP70在HCC中的平均表达指数分别为3.43±2.11和3.18±2.13,显著高于肝硬化组及正常对照组1.51±2.19和1.04±1.85及0和0.75±1.39,差异有统计学意义(q分别为6.29、4.13、6.62及7.39,均P<0.01)。Cyclin D1表达与HSP70表达呈正相关(r=0.219,P<0.01)。结论:Cyclin D1与HSP70过度表达,在HCC癌变中起重要作用。
Objective： To study the expression of Cyclin D1 and heat shock protein 70 （HSP70） in hepatocellular carcinomas. Methods：Tissue array was made from 145 patients with HCC, 78 patients with post-hepatitic cirrhosis, and 16 normal controls. Immunohistochemical staining was performed on the slides. Staining index （ SI ） was used to assess the expression of Cyclin D1 and HSP70. Results：The expression of Cyclin D1 and HSP70 were significantly higher in carcinoma （3.43 ± 2.11 and 3.18 ± 2.13 ） than that in cirrhosis （ 1.51 ± 2.19 and 1.04 ±1.85 ） and in normal control （0 and 0.75 ± 1.39） （P 〈 0.01, respectively）. The expression of Cyclin D1 was significantly related to the expression of HSP70 （ r = 0.219 , P 〈 0.01）. Conclusion：The excessive expressions of Cyclin D1 and HSP70 may play an important role in the course of carcinogenesis.
出处
《天津医药》
CAS
北大核心
2008年第8期569-571,I0001,共4页
Tianjin Medical Journal
基金
天津市自然基金资助项目(项目编号:023616511)
天津市应用基础及前沿技术研究计划(项目编号:08JCZDJC23500)
