4Seto M, Yamazaki T, Sonoda J, et al. Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy[J]. Oncol Rep,2002,9(2) :337.
5Graat HCA, Van Beusechem VW, Schagen FHE,et al. Intravenous administration of the conditionally replicative adenovirus Ad5-A24RGD induces regression of osteosareoma lung metastases [ J ]. Mol Cancer,2008,23:7 - 9.
6Tsuji H, Kawaguchi S, Wada T,et al. Concurrent induction of T-cell activation and apoptosis of osteosarcoma cells by adenovirus-mediated B7-1/Fas chimeric gene transfer[J]. Cancer Gene Ther,2003,10( 9 ) :717 - 725.
7Patil SD, Rhodes DG, Burgess DJ. DNA-based therapeutics and DNA delivery systems: a comprehensive review [ J ]. AAPS J, 2005,7 ( 1 ) : E61 - E77.
8Okumura K, Nakase M, Nakamura S,et al. Bax gene therapy for osteosarcoma using cationic 1 iposomes in vivo [ J ]. Oncel Rep, 2007,17(4) :769 -773.
9Nakase M, Inui M, Okumura K, et al. P53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome [ J]. Mol Cancer Ther,2005,4 ( 4 ) :625 - 631.
1Rygaard K, Sorenson GD, Pettengill OS,et al. Abnormalities in structure and expression of the retinoblastoma gene in small cell lung cancer cell lines and xenografts in nude mice[J]. Cancer Res, 1990,50(17):5312-5317.
3ee C, Chang JH, Lee HS,et al. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor[J]. Genes Dev, 2002 ,16(24):3199-3212.
4llan C, De Falco G, Tosi GM,et al. Missing expression of pRb2/p130 in human retinoblastomas is associated with reduced apoptosis and lesser differentiation[J]. Invest Ophthalmol Vis Sci,2002,43(12):3602-3608.
5Li WW, Fan J,Hochhauser D,et al. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines [J]. Proc Natl Acad Sci USA, 1995,92:10436-10440.