摘要
循环肾素血管紧张素系统（renin-angiotensin system，RAS）是重要的血压和水电解质调节系统。近年来研究发现心脏、血管壁、肾脏和脑等组织局部也具有独立的RAS，主要调节局部组织的生长和分化。我们已经认识到局部RAS在组织损伤和修复过程中起着重要作用。在肺损伤中RAS成分的表达和血管紧张素转化酶的升高提示肺存在RAS，血管紧张素Ⅱ至少在部分上介入肺损伤反应。肺循环和肺实质中局部RAS活化可能影响肺损伤的程度。RAS基因多态性研究以及与特殊表型的关系有助于我们深入了解RAS在肺部的作用，为进一步的靶向治疗提供帮助。
Circular renin-angiotensin system（RAS） is an important regulator of blood pressure and electrolyte water system. Recently, the study found that the heart, vascular wall, kidney, brain and other organizations also have an independent local RAS, the main regulator of the local tissue growth, differentiation. Local tissue-based RAS has also been described to play a major role in the injury/repair response. The expression of RAS components and the elevation of angiotensin converting enzyme in lung injury suggests the existence of a pulmonary RAS. Angiotensin Ⅱ could mediate, at least in part, the response to lung injury. Activation of a local RAS within the pulmonary circulation and lung parenchyma may influence the extent of lung injury. The presence of common polymorphisms in RAS genes and their study in relation to specific physiological phenotypes will help both our understanding of the role of RAS in the lung and also the targeting of future therapies.
出处
《国际呼吸杂志》
2008年第15期932-935,共4页
International Journal of Respiration
