摘要
目的探讨人群2型糖尿病(DM)的危险因素,为制定相关干预政策及措施提供依据。方法采用病例对照研究方法,病例为在深圳市3间医院就诊及住院的295例2型糖尿病患者,糖尿病诊断按照1999年世界卫生组织(WHO)和国际糖尿病联盟的标准;对照为同期在门诊进行健康体检的214例非糖尿病人群。用统一调查表调查研究对象的人口学特征、环境行为心理学特征(包括吸烟饮酒史、体力活动情况、脑力强度、体育锻炼情况、社会心理因素、膳食营养因素等)、既往病史、家族史等内容,并检测其身高、体重、血压、空腹及餐后2h血糖及血脂等指标。对以上研究因素进行单因素及多因素非条件logistic回归分析。结果多因素非条件logistic回归分析结果表明,年龄(OR=3.119)、工作压力(OR=2.202)、高血脂(LDL-C:OR=5.337)、DM家族史(OR=5.243)是2型糖尿病的危险因素;而文化程度(OR=0.283)、运动锻炼(OR=0.701)是保护因素。结论2型糖尿病是遗传因素与环境因素共同作用的结果。对糖尿病的防治应采取综合措施,尤其对于具有糖尿病家族史者以及中老年人群,更应控制各种危险因素。
Objective To explore the risk factors of type 2 diabetes mellitus （T2DM）, and to provide scientific evidence for prevention and intervention. Methods A hospital - based case control study was conducted among 295 patients of type 2 diabetes mellitus and 214 controls. The cases were acquired from 3 hospitals in Shenzhen and the controls were acquired from health examination population in out - patient clinic of these hospitals. The relationship between risk factors of T2DM were analyzed by unconditional univariate and multivariate logistic regression, Results Age （ OR = 3. 119 ） , work pressure （ OR = 2.202） , hyperlipidemia （ LDL - C ： OR = 5. 337 ） , family history of diabetes mellitus （ OR = 5. 243 ） were major risk factors, while culture level （ OR = 0. 283 ） and exercise （ OR = 0. 701 ） were protect factors of T2DM. Conclusion T2DM is caused by the effect of both genetic and environmental factors, and the comprehensive measures should be adopted for prevention of diabetes mellitus, especially to the people with family history of diabetes mellitus and the elderly group.
出处
《华南预防医学》
2008年第4期49-52,共4页
South China Journal of Preventive Medicine
关键词
2型糖尿病
危险因素
病例对照研究
Type 2 diabetes mellitus
Risk factors
Cases - control study
