摘要
目的观察氨酚羟考酮片(泰勒宁)口服给药在人工流产(人流)中的镇痛效果、宫颈松弛度和不良反应。方法选择自愿接受人流的健康未产妇150例,采用双盲随机对照试验分为三组,每组50例,Ⅰ组口服氨酚羟考酮片,II组口服氯芬待因复方片,III组为对照组(口服维生素C),三组均1 h后行人流术。按世界卫生组织疼痛分级标准观察镇痛效果,宫颈松弛度,术毕记录不良反应。结果Ⅰ组和II组镇痛效果比较有显著性差异(P<0.05),Ⅰ组I、I组与III组比较有显著性差异(P<0.05)。Ⅰ组宫颈松弛,与II组和III组比较有显著性差异(P<0.05)。III组不良反应明显高于其他两组(P<0.05)。结论人流术前口服氨酚羟考酮片镇痛效果确切、方法简便、无创、宫颈松弛作用良好、不良反应少,值得推广应用。
Objective：To observe the effect of oxycodone/acetaminophen tablet（Tylox） on analgesia,cervical relaxation and its side-effects in induced abortion.Methods： One hundred and fifty healthy nullipara who requested the termination of their early pregnancy volunteered in this double blind randomized controlled study.The women were divided into 3 groups,with 50 in each group,and treated with Tylox（Group 1）,diclofenac sodium and codeine phosphate tablets（Group 2）,and vitamin C（placebo,Group 3） respectively,one hour before induced abortion.The analgesic effect（evaluated according to the 4-level pain grading method provided by WHO）,degree of cervical relaxation and side-effects were observed.Results： The results showed that the analgesic effect in Group1 was significantly better than that in group 2（P〈0.05）.Either Group 1 or 2 showed a significantly better analgesic effect than Group 3（P〈0.05）.Tylox in Group 1 made cervix more relaxed when compared with the other two groups（P〈0.05）.The side-effects found in Group 3 were more serious than those of the other two groups（P〈0.05）.Conclusion： Taking Tylox tablets before induced abortion was surely effective in pain relief.This method is simple,convenient and noninvasive.It also can make cervix more relaxed with fewer side-effects.It deserves to be promoted and used widely.
出处
《生殖医学杂志》
CAS
2008年第4期266-268,共3页
Journal of Reproductive Medicine
关键词
氨酚羟考酮片
氯芬待因片
口服给药
人工流产术
镇痛
Oxycodone and acetaminophen tablets
Diclofenac sodium codeine phosphate tablets
Orally
Induced abortion
Analgesia
