摘要
目的评价坎地沙坦同苯那普利治疗高血压病的疗效及其对血脂、肾功能的影响及副作用。方法坎地沙坦组,96例,8～16mg/d;苯那普利组,84例,10～20mg/d,均治疗8周。治疗前后所有参与者测血压和测定胆固醇、甘油三脂、肾功能。结果监测血压显示坎地沙坦组降压与苯那普利组无差异,对胆固醇、甘油三脂没有影响,有降低尿酸的作用。与苯那普利组相比,咳嗽发生率低,并能改善肾功能及保护内皮细胞功能。结论坎地沙坦同苯那普利治疗轻、中度高血压病安全、有效,对血脂、肾功能无影响。坎地沙坦有降低尿酸的作用,咳嗽发生率低。
Objective To compare the therapeutic effects of candesartan and benazepril in the essential hypertension. Methods Ninty six patients were treated with eandesartan （ 8 ～16mg/d ） while eighty four patients were treated with benazepril （ 10 ～ 20mg,/d ） for eight weeks. Blood pressure was monitored and blood lipid,renal function and blood cholesterin and plasma renin activity（PRA） were examined before and ＇after the treatment. Results Blood pressure showed no difference between the two groups. Candesartan had no effect on TG and TC but it decreased the level of urine acid. The incidence of cough was lower in candesartan group. Conclusion Candesartan is effective and safe treatment for hypertension,which can decrease the level of urine acid in blood and has lower incidence of cough.
出处
《潍坊医学院学报》
2007年第6期511-512,共2页
Acta Academiae Medicinae Weifang
