摘要
目的:探讨食管癌组织中肥大细胞(mast cell,MC)亚型的变化及其浸润程度与食管癌临床病理特征的关系。方法:采用双重免疫组化染色方法对90例食管癌根治术手术标本中MC进行检测,并探讨MC亚型T型、TC型和C型与食管癌的组织学分级、浸润深度及淋巴结转移之间的关系。结果:食管癌组织内的MC主要分布于癌旁交界区。食管癌中MCT和MCTC两种亚型MC的表达与食管癌浸润深度及淋巴结转移呈显著的负相关性,而MCC型MC的表达与癌组织浸润深度及转移无关。结论:癌间质内MCT和MCTC型MC的浸润可能具有抑制食管癌生长及转移的作用。MC浸润的数量与食管癌的生物学行为有相关性,对食管癌患者预后评估有一定的参考价值。
Objective： To investigate the relationship between mast cell subtypes and clinical pathological properties of esophageal carcinoma. Methods： Tumor tissues from 90 patients with esophageal carcinoma were collected and stained with double labeling immunohistochemistry. The gender, histological grades, depth of invasion, lymph node metastasis rate, mast cell subtypes and distant metastasis were analyzed. Results： Mast cells resided predominantly in the marginal area of the tumors. The density of the MCTC or MCT, but not MCC, was negatively correlated with the depth of tumor invasion and lymph node metastasis. Conclusion： Correlations exist between mast cell subtypes and the biological behaviors of esophageal carcinoma. Mast cell infiltration in the matrix of the tumors may play an important role in preventing invasion and metastasis of esophageal carcinoma. Mast cells may be valuable for establishing a prognosis for esophageal carcinoma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2008年第15期881-883,共3页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金资助(编号:30671932)
关键词
肥大细胞亚型
食管肿瘤
免疫组织化学
Mast ceil subtype
Esophageal carcinoma
Immunohistochemistry
