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叶酸对老年高血压患者血浆Hcy及血管内皮功能的影响 被引量：6

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摘要 将50例轻、中度老年高血压患者随机分为观察组(降压药+叶酸治疗)及对照组(降压药治疗),分别采用免疫荧光法、亚硝酸盐法及放免法测定血浆同型半胱氨酸(Hcy)、NO及内皮素1(ET-1)的水平。结果与治疗前及对照组比较,观察组治疗12周后,Hcy、ET-1下降,NO升高(P均<0.01);Hcy与ET-1呈正相关,与NO呈负相关(r=0.6518、-0.6090,P均<0.05)。提示叶酸可能是通过降低Hcy而改善老年高血压患者的血管内皮功能。
作者 李施勇 许开宁 黄进弟 符永健
机构地区 海南省安宁医院
出处 《山东医药》 CAS 北大核心 2008年第22期40-41,共2页 Shandong Medical Journal
关键词 叶酸 老年高血压 同型半胱氨酸 血管内皮功能
分类号 R544.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献5

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二级参考文献12

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共引文献83

同被引文献31

  • 1Muda P, Kampus P, Zilmer M, et al. Effect of antihy- pertensive treatment with candesartan or amlodipine on glutathione and its redox status, homocysteine and vita-min concentrations in patients with essential hypertension[ J]. J Hypertens,2005,23 ( 1 ) : 105-12.
  • 2Ozkan Y, Ozkan E, Simsek B. Plasma total homocys- teine and cysteine levels as cardiovascular risk factors in coronary heart disease [ J ]. Int J Cardiol, 2002,82 ( 3 ) : 269 -77.
  • 3Gottsater A, Forsblad J, Mattiasson I,et al. Decreasing plasma endothelin - 1 and unchanged plasma neopterin during folate supplementation in hyperhomocysteinemia [J]. Int An9iol,2002,21 (2) :158-64.
  • 4Chia S, Wilson R, Ludlam CA, et al. Endothelial dys- function in patients with recent myocardial infarction and hyperhomocysteinaemia: effects of vitamin supplementation[ J]. Clin Sci (Lond) ,2005,108 ( 1 ) :65-72.
  • 5Wang X, Qin X, Demirtas H, et al Efficacy of fofic acid supplementation in stroke prevention [J]. a meta-analysis Lancet, 2007, 369: 1876-1882.
  • 6Chia S, Wilson R, Ludlam CA, et al. Endothelial dys-function in patients with recent myocardial infarction and hyperhomocys- teinaemia: effects of vitamin supplementa-tion [J]. Clin Sci (Lond), 2005, 108 (1): 65-72.
  • 7Chia S, Wilson R, Ludlam CA, et al. Endothelial dys-function in patients with recent myocardial infarction and hyperhomocys-teinaemia: effects of vitamin supplementa-tion [J]. Clin Sci (Lond), 2005, 108 (1): 65-72.
  • 8Muda P, Kampus P, Zilmer M, et al. Effect of antihy-pertensive treatment with candesartan or amlodipine on glutathione and its re- dox status, homocysteine and vita- min concentrations in patients with essential hyperten-sion [J]. J Hypertens, 2005, 23 (1): 105.
  • 9Ozkan Y, Ozkan E, Simsek B. Plasma total homocys-teine and cysteine levels as cardiovascular risk factors in coronary heart dis- ease [J]. intJ Cardiol, 2002, 82 (3): 269-77.
  • 10ChiaS, Wilson R, Ludlam CA, et al. Endothelial dysfunction in pa-tients with recent myocardial infarction and hyperhomocysteinaemia :effects of vitamin supplementation [ J]. Clin Sci ( Lond),2005,108(1) ; 65 -72.

引证文献6

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山东医药
2008年 第22期

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