摘要
为延长超氧化物歧化酶（ＳＯＤ）在体内存留时间以提高血液相容性，防治缺血、缺氧过程中活性氧造成的组织损伤，以红细胞作为ＳＯＤ载体，采用透析技术将ＳＯＤ包入红细胞内，进行了体外摇床及贮存实验，结果证明ＳＯＤ可包入红细胞，同时ＳＯＤ在３７℃摇床上最初８ｈ活性保持稳定，此种细胞在４℃下活性可至少保持一周，红细胞载体在临床和特种环境医学上将有一定实际意义。
In order to prolong the in vivo half-life of Superoxide Dismutase (SOD) to improve the blood compatibility and to treat tissue injuries caused by activated oxygen during ischemia and hypoxia,erythrocytes were used as SOD carrier.The entrapment of SOD into rabbit erythrocytes was successfully employed.It demonstrated in vitro experiment that SOD activity maintained a stable level in the first 8 hours, and these erythrocytes can be stored at 4℃for one week without loss of activity.The SOD carrier erythrocytes might be useful in clinical and special environmental medicine.
出处
《航天医学与医学工程》
CAS
CSCD
1997年第6期430-433,共4页
Space Medicine & Medical Engineering
关键词
超氧化物歧化酶
载体
红细胞
缺血
缺氧
superoxide dismutase carrier erythrocytes ischemia hypoxia
