摘要
目的探讨慢性阻塞性肺疾病(COPD)患者治疗前后血清SOD和T淋巴细胞亚群分布状况和改变。方法分别应用放射免疫分析和单克隆抗体法对33例COPD患者进行治疗前后血清SOD和T淋巴细胞亚群的检测,并与35名正常健康人作比较。结果COPD患者在治疗前血清SOD、T淋巴细胞CD4/CD8值水平显著低于正常人组(P<0.01),经治疗3个月后,SOD水平与正常人比较差异无显著性(P>0.05),而CD4/CD8值水平与正常人组比较差异有显著性(P<0.05)。结论检测COPD患者治疗前后血清SOD和T淋巴细胞亚群值水平对其病情和预后判断均有重要的临床价值。
Objective To explore the changes of serum SOD levels and T-cell subset distribution type before and after treatment in patients with chronic obstructive pulmonary diseases. Methods Serum SOD levels were measured with RIA and T-cell subset distribution type detected with monoclonal antibody technique both before and after treatment in 33 patients with chronic obstructive pulmonary diseases as well as 35 controls. Results Before treatment the serum levels of SOD as well as the CD4/CD8 ratios were significantly lower in the patients than those in controls （P 〈 0. 01 ） . After 3 months＇treatment,the serum SOD levels in patients were not much different from those in the controls （ P 〈 0. 05 ）, while the CD4/CD8 ratios were still significantly lower （ P 〈 0. 05）. Conclusion Determination of serum SOD levels and T-cell subset distribution type were useful in the study of cellular immunofunetion disturbance during recovery in patients with chronic obstructive pulmonary diseases.
出处
《淮海医药》
CAS
2008年第6期486-487,共2页
Journal of Huaihai Medicine
关键词
慢性阻塞性肺疾病
超氧化物歧化酶
T淋巴细胞亚群
Chronic obstructive pulmonary diseases （COPD）
Superoxide dismutase （SOD）
T-cell subset
