摘要
室温下,以吲哚和邻甲酰苯甲酸为原料,通过Amberlyst 15(15wt%)催化的傅-克反应,高产率合成得到一系列3-吲哚取代的苯酞类化合物.并通过1HNMR,13CNMR,红外光谱,高分辨质谱确证了产物的结构.
A mild and simple method for the synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reaction of indoles with 2-formylbenzoic acids catalyzed by an acidic cation exchange resin Amberlyst 15 has been developed. The reaction affords a wide range of 3-indolyl-substituted phthalides in high yield. The structures of the corresponding products were confirmed on the basis of ^1H NMR, ^13C NMR, IR and HRMS spectra.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2008年第8期1479-1482,共4页
Chinese Journal of Organic Chemistry
基金
中国科学院知识创新工程方向性(Nos.KSCX2-YWR-23,KJCX2-YW-H-07)资助项目
