摘要
N-甲基-N-对溴苯基-α-甲硫基乙酰胺与高碘酸钠反应得到N-甲基-N-对溴苯基-α-甲亚磺酰基乙酰胺,收率93%,再在对甲苯磺酸作用下发生分子内的Pummerer反应,得到5-溴-1-甲基-3-甲硫基-吲哚-2-酮,收率78%,进一步与二乙酰氧基碘苯反应,得到标题化合物,收率63%,通过IR1、3CNMR1、HNMR等波谱方法证明了产物的结构。
Reaction of N-（4-bromophenyl）-N-methyl-α-methylthio-acetamide with NaIO4 gave N-（4-bromo-phenyl）-N-methyl-α-methylsulfinyl-acetamide in 93% yield. 5-Bromo-1-methyl-3-methylthio indol-2-one was obtained by Pummerer reaction of N-（4-bromo-phenyl）-N-methyl-α-methylsulfinyl-acetamide with p-toluenesulfonic acid in 78 % yield. Reaction of 5-bromo-1-methyl-3-methylthio-indol-2-one with iodobenzene diacetate gave 5-bromo-1-methylisatin in 63% yield.
出处
《化学试剂》
CAS
CSCD
北大核心
2006年第4期241-242,共2页
Chemical Reagents
