摘要
目的:了解替米沙坦治疗高血压有效性和安全性的差异。方法:应用Meta分析对17篇文献中18项研究替米沙坦与其他降压药物治疗高血压的有效性、安全性进行同质性检验及合并效应量的估计。结果:Meta分析结果显示替米沙坦与对照组有效性和安全性的同质性检验结果显示同质性较好(x2=13.36,P=0.71及x2=14.39,P=0.42),故采用固定效应模型,合并后效应值组间差异有统计学意义(Z=3.21,P<0.05及Z=3.83,P<0.05)。结论:替米沙坦治疗高血压的疗效总体上优于对照组,且其安全性也相对较高。
OBJECTIVE To assess the efficacy and safety of telmisartan in the treatment of hypertension. METHODS The efficacy and safety of telmisartan in treating hypertension were comprehensively evaluated with the meta-analysis in homogeneity tests and combined tests in 18 studies. RESULTS The homogeneity test showed that the cited studies of the efficacy and safety were homogeneous with x^2= 13.36, x^2 = 14. 39, P〉0. 05. In the combined tests, meta-analysis indicated that high statistical significance was detected between telmisartan and control group on efficacy and safety with Z= 3. 21 ,P〈0. 05 and Z= 3. 83,P〈0. 05. CONCLUSION The effectiveness of telmisartan in the treatment of hypertension is significantly superior to control group and is safer and has fewer adverse effects.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第15期1294-1298,共5页
Chinese Journal of Hospital Pharmacy
