摘要
应用免疫组织化学（ＳＰ）方法研究了１４例正常前列腺、５６例前列腺增生和３３例前列腺癌组织中表皮生长因子受体（ＥＧＦＲ）的表达。结果显示，ＥＧＦＲ分布于上皮细胞；前列腺癌和增生组织中ＥＧＦＲ阳性率分别为９３９％和８７５％，均明显高于正常前列腺５７１％；ＥＧＦＲ表达与癌细胞分化程度有关，各病理分期中ＥＧＦＲ表达也有差别。提示ＥＧＦＲ与前列腺增生及癌变的发生有关，可作前列腺癌生物学行为的判断指标。
he expression of epidermal growth factor receptor (EGFR) was determined in 14 cases with normal prostate and 56 cases with benign prostatic hyperplasia (BPH) and 33 cases with prostate carcinoma (PC) using immunohistochemical methods.The immunoreactivity of EGFR was located in the epithelial cells.There was significant higher expression of EGFR in PC (93.9%) or BPH (87.5%) than that in the normal prostates (57.1%).There was a significant positive correlation bewteen EGFR expression and tumor grades.The results suggest that over expression of EGFR may play an important role in the pathogenesis of BPH and PC.
出处
《湖南医学》
1997年第6期329-330,共2页
Hunan Medical Journal
关键词
前列腺肿瘤
表皮生长因子
受体
免疫组织化学
prostatic hypertrophy prostatic neoplasms cancer receptors,epidermal growth factor immunohistochemistry
