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ApoEε4等位基因与老年人术后认知功能障碍的相关性研究 被引量：2

Correlation between the Apolipoprotein ε4 Allele and Postoperative Cognitive Dysfunction in the Elderly
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摘要 目的研究载脂蛋白E(ApoE)ε4等位基因与老年人术后认知功能障碍(POCD)之间的相关性。方法使用中文版韦氏成人智力量表(WAIS)和韦氏记忆量表(WMS)对患者进行术前1d和术后7d的神经、精神功能测试。对30例POCD老年患者和30名健康老年人(对照组)做ApoE的基因分型鉴定并进行比较。结果ApoEε3/ε4型频率(28.3%)和ApoEε4等位基因频率(17.8%)均高于对照组(9.6%,4.9%)。两组比较有统计学意义(P<0.01)。结论ApoEε4等位基因是对老年人认知功能产生有害影响的因素,可使认知障碍加重;老年人POCD和ApoEε4基因的关系在统计学上存在着相关性。 Objective To study the correlation between the apolipoprotein ε4 allele and postoperative cognitive dysfunction in the elderly. Methods The patients （pts） were divided into postoperative cognitive dysfunction （POCD） group and normal group. Cognitive function was evaluated by nine neuro - psychological tests before operation, at one week after operation. ApoE allele genotype were detected and compared. Results The frequencies of ApoEε3/ε4 phenotype（28.3 % ） and ApoEε4 alleles （17.8 %） were higher in POCD group than that in the normal group （P〈0. 01）. Conclusion ApoEε4 allele gene could be regarded as a harmful factor to senile cognitive function. The ApoE genotype had a close correlation with postoperative cognitive dysfunction in the elderly.
作者 吴涯雯 廖志捷 詹鸿 陈浩文 张双全 陈郡兴
机构地区 广州医学院第三附属医院 广东省广州市南方医院
出处 《中西医结合心脑血管病杂志》 2008年第8期921-922,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 广州市卫生局科研基金资助项目(No.2006-YB-173) 广州市中医药中西医结合科研立项课题(No.2006B48)
关键词 载脂蛋白E 认知障碍 手术后并发症 apolipoproteins E cognition disorders elderly
分类号 R749.1 [医药卫生—神经病学与精神病学]
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参考文献8

  • 1Silbert BS, Maruff P, Evered LA,et al. Detection of cognitive decline after coronary surgery: A comparison of computerized and conventional tests[J]. Br J Anaesth,2004,92(6):814 - 820.
  • 2Leung JM, Sands LP, Vaurio LE, et al. Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients[J]. Br J Anaesth, 2006,96 (6) : 754 - 760.
  • 3Wenham PR, Price WH, Blundell G. Apolipoprotein E genotyping by one- stage PCR[J]. Lancet, 1991,337;1158-1159.
  • 4庄心良,曾因明,陈伯銮.现代麻醉学[M].第3版.北京:人民卫生出版社,2006,443,525,1035
  • 5杨旭东,吴新民,王东信,朱姜华,李军,单国瑾,马琼,苏玉.冠脉搭桥术患者载脂蛋白Eε4基因与术后认知功能障碍的关系[J].中华麻醉学杂志,2005,25(2):94-97. 被引量：7
  • 6Newman MF,Croughwell ND, Bluemental JA,et al. Predictors of cognitive decline after cardiac operation [J]. Ann Thorac Surg, 1995,59: 1326- 1330.
  • 7Tardiff BE. Preliminary report of a genetic basis for cognitive decline after cardiac operation[J]. Ann Thorae Surg, 1997,64:715 - 720.
  • 8Abildstrom H,Christiansen M,Siersma V,et al. Apolipoprotein E genotype and cognitive dystunction at ter non cardiac surgery[J]. Anesthesiology, 2004,101 : 855 - 861.

二级参考文献13

  • 1Newman MF, Croughwell ND, Bluernental JA, et al. Predictors of cognitive decline after cardiac operation. Ann Thorac Surg, 1995,59: 1326-1330.
  • 2Edawrdson J, Morris C. The genetics of Alzheimer′s disease. BMJ, 1998,317: 361-362.
  • 3Fillenbaum GG, Landerman LR, Blazer DG, et al. The relationship of ApoE genotype to cognitive functioning in older African-American and Caucasian community residents. J Am Geriatr Soc,2001,49:1148-1155.
  • 4Alberts MJ. ApoE genotype and survival from intracerebral haemorrhage.Lancet, 1995,346:575.
  • 5McCarron MO, Delong D, Alberts MJ, et al. ApoE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis. Neurology,1999,53:1308-1311.
  • 6Tardiff BE. Preliminary report of a genetic basis for cognitive decline after cardiac operations. Ann Thorac Surg, 1997,64: 715-720.
  • 7Steed L, Kong R, Stygall J, et al. The role of apolipoprotein E in cognitive decline after cardiac operation. Ann Thorac Surg, 2001,71:823-826.
  • 8James E, Murray RK, Senti M, et al. Restriction iaotyping of human Apo E by gene and amplification and cleavage with Hhal I. J Lipid Res,1990,31: 545-548.
  • 9Murphy GM, Taylor J, Kraemer HC, et al. No asosciation between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer′s disease. Am J Psychiatry, 1997,154:603-608.
  • 10Deary IJ, Whiteman MC, Pattie A, et al. Cognitive change and the AroE epsilon 4 allele. Nature,2002,29, 418:932.

共引文献58

同被引文献32

  • 1Dodds C,Allision J.Postoperative cognitive deficit in the elderly surgical patient[J].Br J Anaesth,1998,81 (3):449-462.
  • 2Papaioannou A,Fraidakis O,Balalis C,et al.The impact of the type of anaesthesia on cognitive status and delirium during the first postoperative days in elderly patient[J].Eur J Anaesthesiol,2005,22 (7):492-499.
  • 3Rohan D,Buggy DJ,Crowley S,et al.Increased incidence of postoperative cognitive dysfunction 24h after minorsurgery in the elderly[J].Can J Anaesth,2005,52(2):137-142.
  • 4Silverstein JH,Timberger M,Reich DL,et al.Central nervous system dysfunction after noncardiac surgery and anethesia in the elderly[J].Anesthesiologists,2007,106 (3):622-628.
  • 5Moller JT,Cluitmans P,Rasmussen LS,et al.Long-term postoperative cognitive dysfunction in elderly:ISPOCD1 study[J].Lancet,1998,351 (9106):857-861.
  • 6Futterer CD,Maurer MH,Schmitt A,et al.Alterations in rat brain proteins after desflurane anesthesia[J].Anesthesiology,2004,100(2):302-308.
  • 7Rasmussen LS,Johson T,Kuipers R,et al.Does anesthesia cause postoperative cognitive dysfunction?[J].Anaesthesiol Scand,2003,47 (3):260-266.
  • 8Browne SM,Halligan PW,Wade DT,et al.Postoperative hypoxia is a contributory factor cognitive impairment after cardiac surgery[J].J Thorac Cardiovasc Surg,2003,126(4):1061-1064.
  • 9Bryson GL,Wyand A.Evidence based clinical up date:general anesthsia and the risk of delirium and postoperative cognitive dys-function[J].Can J Anaesth,2006,53 (4):669-677.
  • 10Masliah E,Mallory M,Veinbergs L,et al.Alterations in apolipoprotein E expression during aging and neurodegeneration[J].Prog Neurobiol,1996,50(4):493-503.

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二级引证文献18

中西医结合心脑血管病杂志
2008年 第8期

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