摘要
目的探讨急性脑梗死患者抗凝纤溶系统指标及血小板活化指标的变化规律。方法以同期健康体检者为对照组,对急性脑梗死患者进行抗凝血酶-Ⅲ(AT-III)、D-二聚体(D-D)含量及活化血小板膜糖蛋白CD62p、血小板平均体积的测定。结果与对照组比较,脑梗死组AT-Ⅲ活性明显降低,D-二聚体显著升高(P<0.01),活化血小板膜糖蛋白CD62p及血小板平均体积显著升高(P<0.01和0.05)。结论抗凝纤溶系统及血小板活化指标与脑梗死的发生发展密切相关,检测抗凝纤溶系统及血小板活化指标对脑梗死的诊断及治疗有一定的临床意义。
Objective Study the changes of platelets＇ parameters and anti-coagulate and fibrinolytic system＇ parameters in patients with cerebral infarction. Methods the antithrombin Ⅲ ,D-Dimer,mean platelet volume （MPV） and CD62P in patients with cerebral infarction were measured, at the same time, the healthy people were analyzed as controls. Results In patients with cerebral infarction, D- Dimer and CD62P were （ 1.10 ± 0.38） mg/L and（ 12.2 ±2.4） %, which were higher than those of healthy people （0.46± 0.26）mg/L, （2.3 ±0.7） %, the antithrombin was （75.3±15.6） % in patients with cerebral infarction and （ 110 ± 18.67） in controls, the difference was significant（ P 〈 0.01 ）, MPV were （ 12.3 ± 1.25） fl in patients with cerebral infarction and （ 10.7 ± 1. 25） fl in controls, P 〈 0.05. Conclusion The activity of platelet and fibrinolytic system were enhanced and the anti-coagulate system were decreased in patients with cerebral infarction, the anti-coagulate and fibrinolytic system＇ and platelet may play some important role in the pathogenesis and development of patients with cerebral infarction.
出处
《中国实验诊断学》
2008年第7期866-867,共2页
Chinese Journal of Laboratory Diagnosis
