摘要
目的研究慢性阻塞性肺疾病（COPD）患者血浆生长素释放肽（ghrelin）水平及其与营养状态的相关性，探讨ghrelin在COPD营养代谢中的作用。方法检测53例COPD患者[营养不良组（COPDA组）31例，营养正常组（COPDB组）22例]及20例健康对照组的血浆生长素释放肽水平，并测量体重指数，理想体质量百分比，上臂中部臂围、血清白蛋白、血淋巴细胞计数等评估营养状况，分析血浆生长素释放肽与备营养参数的相关性。结果营养不良组COPD血浆生长素释放肽水平高于营养正常组COPD和健康对照组，且其水平与体重指数、理想体质量百分比、上臂中部臂围呈负相关，而与血清白蛋白、血总淋巴细胞计数无相关性。结论血浆生长素释放肽参与了COPD患者营养不良状况的调节，其升高是机体在营养不良状态下机体反馈性生理调节的结果。
Objective To investigate the correlation between the serum ghrelin levels and nutrition state in the patients with chronic obstructive pulmonary disease（COPD）, as well as to explore the role of ghrelin in the nutrition metabolism. Methods Fifty-three COPD patients were observed, thirty-one of them were with malnutrition （group A）,twenty-two COPD patients with normal nutrition status（group B）,and twenty were healthy controls. Serum ghrelin, and nutritional parameters such as body mass index（BMI）,ideal body weitht （% IBW）, mid-upper arm cricumference（MAC）,serum albumin（ALB）,total lymphocyte counts（LYM） were determined. The correlation between ghrelin and nutritional parameters was analysed. Results The level of serum ghrelin in group A were significantly higher than those in group B and in healthy controls. And the serum ghrelin showed a negative correlation with BMI, % IBW, MAC, but there was no correlation between serum ghrelin level, ALB and LYM. Conclusion Ghrelin participated in the nutrition metabolism in patients with COPD, it would become much higher because of malnutrition in COPD.
出处
《中国基层医药》
CAS
2008年第6期909-910,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肺疾病
慢性阻塞性
促生长素释放激素
Pulmonary disease
Somatotropin-releasing hormone, chronic obstructive
