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CEA、p53、Ki-67、GST-π在大肠癌组织表达及其相关性研究 被引量:7

Expression and Correlation of CEA,p53,Ki-67 and GST-π in Colorectal Carcinoma Tissues
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摘要 [目的]探讨大肠癌中CEA、p53、Ki-67、GST-π的表达与临床病理分期之间的关系。[方法]回顾性分析2004年1月~2007年6月收治的63例大肠癌患者的临床、病理资料,对肿瘤石蜡标本采用免疫组化SP染色法检测CEA、p53、Ki-67、GST-π,分析其免疫组化特点及其与临床病理之间的关系。[结果]CEA、p53、Ki-67、GST-π在大肠癌切片中的阳性率依次为95.2%、55.6%、52.4%、82.5%。p53、Ki-67与肿瘤的Dukes'分期和淋巴结转移有关,在Dukes'C、D期的阳性表达率明显高于Dukes'A、B期患者。p53、Ki-67表达之间呈现明显的正相关;GST-π和p53两者的表达呈正相关。[结论]大肠癌CEA、p53、Ki-67、GST-π表达与其发生发展和浸润转移密切相关,联合检测对了解大肠癌的生物学行为和判断患者预后有一定的实用价值。
出处 《肿瘤学杂志》 CAS 2008年第7期575-577,共3页 Journal of Chinese Oncology
基金 南京医科大学重点基金项目(07002)
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