摘要
研究中国人血管紧张素转换酶（ＡＣＥ）基因多态性与原发性高血压的关系。方法应用聚合酶链反应对１１６例健康汉族人及１２７例原发性高血压患者进行ＡＣＥ基因多态性检测，并测定血清ＡＣＥ活性。结果＜６０岁高血压患者中Ｄ等位基因频率（０．４５７）显著高于对照组（０．３５８，Ｐ＜０．０５）；而≥６０岁高血压患者Ｄ等位基因频率明显降低（０．３０４）。两组中均发现ＡＣＥ基因型与血清ＡＣＥ活性相关（Ｐ＜０．０５）。结论Ｄ等位基因可能是中国人原发性高血压的危险因子。
Aim To investigate the association between angiotensin Iconverting enzyme(ACE) gene polymorphism and essential hypertension in a Chinese population.\ Methods The insertion/deletion polymorphism of ACE gene was detected by polymerase chain reaction in 127 hypertensive patients and 116 normotensive subjects.\ Serum ACE activity was also measured.\ Results The frequency of the ACE D allele was higher in the hypertensives aged<60 years(0457) than in normotensives(0385)(P<005).\ An apparent loss of the D allele was observed in the hypertensives aged≥60 years(0304).\ Significant relationships between the ACE genotype and serum ACE activity were found in both groups(P<005).\ Conclusion These findings suggest the ACE D allele may be a genetic risk factor for essential hypertension in Chinese.
出处
《高血压杂志》
CSCD
1997年第4期272-274,共3页
Chinese Journal of Hypertension
关键词
高血压
ACE
多态现象
聚合酶链反应
essential hypertension
angiotensin Iconverting enzyme
polymorphism(genetic)
polymerase chain reaction
