微泡对比剂与基因治疗
Microbubble contrast agent and gene therapy
摘要
随着超声造影和微泡制备技术的不断发展,微泡对比剂不仅成为诊断工具,而且在基因治疗方面展现出广阔的应用前景。微泡对比剂作为"空化核"起到协同超声辐照的作用,能显著提高超声介导的基因转染,是一种安全的靶向基因转运载体,具有潜在的应用价值。
基金
国家自然科学基金资助(No.30470467)
参考文献22
-
1Aoi A, Watanabe Y, Mori S, et al. Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound[J]. Ultrasound Med Biol, 2008, 34(3): 425-434.
-
2Hosseinkhani H, Kushibiki T, Matsumoto K, et al.Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation [ J ]. Cancer Gene Ther, 2006, 13 (5): 479-489.
-
3Hwang LH. Gene therapy strategies for hepatocellular carcinoma [J]. J Biomed Sci, 2006, 13(4): 453-468.
-
4Liang HD, Lu QL, Xue SA, et al. Optimisation of ultrasound-mediated gene transfer (sonoporation) in skeletal muscle cells [J]. Ultrasound Med Biol, 2004, 30( 11 ): 1523-1529.
-
5Michel MS, Erben P, Trojan L, et al. Acoustic energy: a new transfection method for cancer of the prostate, cancer of the bladder and benign kidney cells[J]. Anticancer Res, 2004, 24(4): 2303-2308.
-
6Mehier-Humbert S, Bettinger T, Yan F, et al. Ultrasound mediated gene delivery: kinetics of plasmid internalization and gene expression[J]. J Control Release, 2005, 104( 1 ): 203-211.
-
7Akowuah EF, Gray C, Lawrie A, et al. Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model [J ]. Gene Therapy, 2005, 12(14): 1154-1157.
-
8Zhou QH, Miller DL, Carlisle RC, et al. Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation [ J ]. J Control Release, 2005, 106 ( 3 ) : 416-427.
-
9Rahim AA, Taylor SL, Bush NL, et al. Spatial and acoustic pressure dependence of microbubble mediated gene delivery targeted using focused ultrasound[J]. J Gene Med, 2006, 8( 11 ): 1347-1357.
-
10Unger EC, Hersh E, Vannan M, et al. Local drug and gene delivery through microbubbles [J ]. Prog Cardiovasc Dis, 2001, 44 (1): 45- 54.
-
1肖雁冰,王智彪,李发琪.新型超声微泡对比剂——Sono Vue的应用进展[J].国外医学（临床放射学分册）,2005,28(2):106-110. 被引量：16
-
2陈林,詹维伟,刘振华,姚洁洁,周建桥,陈曼,芮文斌.诊断超声联合微泡对比剂辐照不同时间对兔正常睾丸组织的影响[J].诊断学理论与实践,2010,9(2):161-165. 被引量：3
-
3朱学平,张海霞,毕美萍,陈芙庭.微泡对比剂在附件肿块经阴道超声造影中的应用价值[J].现代实用医学,2013,25(11):1295-1297. 被引量：2
-
4顾永杰.超声造影在肝脏局灶性病变中的应用[J].中国城乡企业卫生,2016,31(3):63-64. 被引量：2
-
5林艳端,申锷,胡兵.低频超声联合微泡对比剂开放血-前列腺屏障的研究进展[J].中华临床医师杂志（电子版）,2013,7(14):194-195. 被引量：5
-
6彭昊,黄磊,丁帅,李彬彬,甘经岳,许顺恩.超声破坏微泡法介导增强型绿色荧光蛋白质粒转染兔股骨头组织的安全性及可行性(英文)[J].中国组织工程研究与临床康复,2011,15(50):9314-9318. 被引量：1
-
7罗敏,王英,赵彦功,李卉,高娃.1例六氟化硫微泡致过敏性休克的急救与护理[J].中国急救复苏与灾害医学杂志,2012,7(10):990-990. 被引量：6
-
8吴桂林,李明意,孙丕绛,徐晓红,林满洲,杨永光,张谷裕,刘国华,徐浩.门静脉注射超声微泡促进肝脏EGFP质粒表达[J].广东医学院学报,2011,29(3):245-247.
-
9平其能,郭健新.脂质体在基因治疗中的应用[J].药学进展,1998,22(2):69-74. 被引量：10
-
10冉玲,李晓倩,蒋欣益,邓锋,宋锦璘,曹礼.超声微泡介导pEGFP-N1转染大鼠牙囊细胞:细胞生物学性质相对稳定[J].中国组织工程研究,2014,18(50):8151-8155. 被引量：1
