摘要
目的:考察胰岛素注射液与注射用头孢地嗪钠在5%葡萄糖注射液中配伍稳定性。方法:观察配伍液外观、测定配伍液pH,不溶性微粒数等,采用HPLC法测定头孢地嗪钠含量,用化学发光免疫法测定胰岛素含量。结果:配伍液在6 h内无明显外观、pH,头孢地嗪钠含量的变化;但不溶性微粒(≥10μm)数在5 h后超过25个/ml,胰岛素含量在4 h后变化超过10%。结论:胰岛素注射液与头孢地嗪钠在5%葡萄糖注射液中室温下可配伍应用,但应在4 h内用完。
Objective： To study the compatible stability of insulin injection mixing with cefodizime sodium for injection in 5% glucose injection. Method： The appearance of mixed solution, pH and the count of the insoluble particles were monitored, cefodizime sodium was determined by HPLC, and insulin was determined by chemiluminescence immunoassay. Result： There was no significant changes in appearance ,pH and the content of cefodizime sodium within 6 h,but the count of insoluble particles （ ≥10 μm） was over 25 per millilitre 5 h, the content changes of insulin was over 10% after 4 h. Conclusion ： Insulin injection mixing with cefodizime sodium for injection in 5% glucose injection can be used at room temperature ,but shoud be used within 4 h.
出处
《中国药师》
CAS
2008年第7期806-808,共3页
China Pharmacist
