摘要
T细胞受体（TCR）Vβ基因 1—20亚家族在识别和杀伤病毒及肿瘤抗原方面各自有着重要的作用。本研究采用单纯性痢疾病毒（HSV-2）感染正常人的外用血淋巴细胞（PBLs）后发现TCR Vβ2,6,7,8基因在体外选择性扩增,而用 HSV-2攻击生殖器单纯疱疹性皮肤病患者不同病程时期的 PBLs时发现 TCRVβ基因的表达水平随病程不同而改变。结果提示Vβ7,8在识别HSV-2时呈选择性扩增而限制 HSV-2的增殖。
T cell receptor(TCR) Vβ1-20 genes have important roles in recognizing viral antigen and tumor antigen. When healthy human peripheral blood lymphocytes (PBLs) were infected with herpes simplex virus-2(HSV-2), TCR Vβ2,6,7 and 8 sub-units were found to be selectively amplified. While PBLs of genitals herpes simplex skin sickness were attacked with HSV-2, the expression level of TCR Vβ subunits genes varied in different clinical stages. The results we. obtained revealed that TCR Vβ 7,8 would compensately amplified when it had recognized the viral antigen as the restricted Vβ subunits to HSV-2.
出处
《上海免疫学杂志》
CSCD
北大核心
1997年第2期98-102,共5页
Shanghai Journal of Immunology
基金
1995年国家自然科学基金39640005资助
