摘要
用ＭｃＡｂ，抗ＣＤ３，ＣＤ３＋ＣＤ２８和ＣＤ２８＋ＣＤ８０激活健康人ＰＢＬｓ，作用于肝癌细胞（ＢＥＬ－７４０２），透射电镜观察其超微结构，发现除抗ＣＤ３可引起部分淋巴细胞诱导性凋亡外，其他组都可介导肝癌细胞凋亡。结果提示ＭｃＡｂ共刺激能促进肿瘤免疫治疗的研究。
Adoption McAb antiCD3,CD3 and CD28,CD28 and CD80 activate lymophocytes of health human peripheral blood,then acted on hepatoma cell that transmission electron microscope observe it hypermicroscopic ultrostructure found that exception antiCD3 lead to lymophocytes apoptosis of part inductive,other group hepatoma cell were mediated apoptosis.The results suggested that McAb costimulate would be promote research of tumour immunotherapy.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1998年第2期154-156,共3页
Chinese Journal of Immunology
基金
国家自然科学基金
广东省科教兴医"五个一"工程重点课题
粤卫科〔1996〕20号资助
关键词
单克隆抗体
共刺激
肝癌
透射电镜
细胞凋亡
McAb costimulate Hepatoma cell Transmissionelectronmicroscope Apoptosis
