摘要
目的探讨网织血小板(RP)检测在血液系统疾病诊断中的初步应用。方法对107例血液病人及100例正常人进行网织血小板的检测,并对它们的检测结果进行单因素方差分析。结果12例ITP病人网织血小板百分比(RP%)测量结果为(28.87±8.91)%(范围从15.16%～44.98%),明显高于正常对照组;4例治疗后的ITP病人RP%为(9.06±3.87)%,与正常对照组无差异;12例AA的RP%为(5.96±3.01)%(范围从2.50%～14.49%),低于正常对照组,RP绝对值为(1.57±1.90)×109/L,结果明显低于正常对照组。36例ALL组RP%为(12.20±5.33)%,30例ANLL组RP%为(10.83±5.16)%,与正常对照组相比差异无统计学意义(P>0.05);8例慢性粒细胞白血病RP绝对值为(139.67±80.06)×109/L,RP绝对值明显高于正常对照组(P=0.000)。5例MDS病人RP%为(21.75±7.37)%,高于正常对照组(P<0.05)。分析了6例病人骨髓巨核细胞检测结果,并与RP%结果进行了对照分析,发现6例病人的网织血小板的检查结果与骨髓巨核细胞检查结果相符。结论RP%及RP在不同血液疾病中的测定结果显示RP%对于血小板减少性疾病的病因诊断有一定的参考价值。
Objective To evaluate the significance of reticulated platelets（RPs） in peripheral blood on the diagnosis of thrombocytopenie disorders. Method The RPs were counted in 107 patients and 100 control subjects. One-way ANOVA was used to analyze the results. Result The average percentage of the RPs in the 12 patients with ITP was （28.87±8.91）%, with a range of 15.16%±44.98%. As compared with the normal group, the patients with ITP had a significantly high percentage of RP （P〈0.01）. The average percentage of the RPs in 4 ITP patients after treatment was （9.06±3.87）%. There was no significant difference of RP percentage between the ITP patients after treatment and normal controls. The average percentage and absolute counts of the RPs in the 12 AA cases were （5.96±3.01）% and （1.57±l.90）×10^9/L, respectively. As compared with the normal group, the patients with AA had a significantly low percentage and low absolute counts of RPs （P〈0.01）. The average percentages of the RPs in the 36 patients with ALL and in the 30 patients with ANLL were （12.20±5.33）% and （10.83±5.16）%, respectively. There was no significant difference of RP percentage between these two groups and normal controls （P〉 0.05）. The average absolute count of the RPs in the 8 patients with CML was （139.67±80.06）×10^9/L. As compared with the normal group, the patients with CML had a significantly higher absolute counts （P=0.000）. The average percentage of the RPs in the 5 patients with MDS was （21.75±7.37）%. As compared with the normal group, the patients with ITP had a significantly higher percentage （P〈0.01）. The megalokaryocytes in bone marrow were analyzed. As compared with the percentage of the RPs, there was no significant difference between two results. Conclusion Reticulated platelet count may contribute to the aetiology determination of the thrombocytopenia. It is also a valuable diagnostic method and a monitoring marker.
出处
《热带医学杂志》
CAS
2008年第6期581-583,591,共4页
Journal of Tropical Medicine
