摘要
目的探讨儿童出生缺陷发生的各种危险因素,为制定出生缺陷干预措施、做到优生优育提供依据。方法采用1∶1配对病例对照研究,对565对病例与对照进行调查,采用SPSS软件对所有调查因素进行单因素χ2检验和多因素的条件logistic回归分析。结果有统计学意义的危险因素是:家庭附近有污染(OR=5.18)、父母近亲结婚(OR=12.37)、有生育畸形儿史(OR=2.52)、孕育期接触有害物质(OR=10.81)、孕育期用药(OR=3.27)、孕育期接触宠物(OR=4.26)、父亲吸烟(OR=1.95)。结论家庭附近有污染、父母近亲结婚、有生育畸形儿史、孕育期接触有害物质、孕育期用药、孕育期接触宠物、父亲吸烟是出生缺陷的危险因素。
Objective To investigate the risk factors of the Birth Defects （B. D） of 0- 5-year-old children in Bengbu so as to explore effective intervention strategy. Methods A 1 ： 1 matched case-control study was conducted to investigate 565 pairs of cases and the control. The data were analyzed for Single- and multiple-factor conditional logistic regression using SPSS software. Results The results of multiple regression model showed that the risk factors of BD were： domestic contamination （OR=5.18）, consanguineous marriage （OR=12.37）, bearing malformation child history （OR = 2.52）, exposure to harmful substance during pregnancy （ OR = 10.81 ）, drug usage during pregnancy （OR =3.27）, pet contacting during pregnancy （OR =4.26）, and father smoking （OR = 1.95）. Conclusions Birth defect risks include domestic contamination, consanguineous marriage, bearing malformation child history, exposure to harmful substance during pregnancy, drug usage during pregnancy, pet contacting during pregnancy, and father smoking.
出处
《疾病控制杂志》
2008年第3期218-220,共3页
Chinese Journal of Disease Control and Prevention
基金
安徽省教育厅自然科学基金(KJ2007B334ZC)
安徽省计生委(05-02)
关键词
畸形
危险因素
病例对照研究
Abormalities
Risk factors
Case-control studies
