期刊文献+

退变腰椎终板MRI表现与其TNF-α的表达及临床疗效的相关性研究 被引量:8

暂未订购
导出
摘要 目的探讨退变腰椎终板MRI表现与其TNF-α表达及临床治疗效果是否具有相关性。方法选取因腰椎退变行椎体间融合术的19例患者,其中MRI检查无改变者7例,ModicⅠ型6例,ModicⅡ型6例。退变终板先行HE染色,光镜下观察软骨形态学变化以确定实验标本,然后用免疫组织化学法检测标本中TNF-α的含量,临床疗效依据手术前后Oswestry功能障碍指数评定。结果在出现Modic改变的腰椎终板中,TNF-α表达比无Modic改变者明显升高(P<0.05),ModicⅠ型TNF-α表达明显高于ModicⅡ型(P<0.05)。ModicⅠ型Oswestry功能障碍指数改善55.28%,ModicⅡ型改善34.27%,无Modic改变者改善48.13%。ModicⅠ型手术效果优于ModicⅡ型。结论退变腰椎终板的MRI改变与TNF-α表达有关,终板中TNF-α的异常表达可能是下腰痛的原因之一,临床疗效与Modic分型有关。
出处 《现代医学》 2008年第3期201-203,共3页 Modern Medical Journal
  • 相关文献

参考文献13

  • 1Mooney V. Where is the pain coming from? [ J ]. Spine , 1987, 12:754-759.
  • 2Modic M T, Steinberg P M, Ross J S, et al. Degenerative disk disease:assessment of changes in vertebral body marrow with MR imaging [ J ]. Radiology, 1988,166 ( 1 Pt 1 ) : 193-199.
  • 3Modic M T, Masaryk T J, Ross J S, et al. Imaging of degenerative disk disease[ J]. Radiology, 1988,168( 1 ) : 177-186.
  • 4龙厚清,周智良,刘少喻,李佛保,梁春祥,于滨生.腰椎MR成像椎间盘终板区Modic征象的诊断价值[J].中国骨与关节损伤杂志,2005,20(12):799-801. 被引量:20
  • 5Weishaupt D, Zanetti M, Hodler J, et al. Painful lumbar disc derangement: relevance of endplate abnormality at MR imaging [ J]. Radiology,2001,218:420.
  • 6Weiler C, Nerlich A G, Bachmeier B E, et al. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls[ J]. Spine ,2005,30( 1 ) :44-54.
  • 7Chataigner H,Onimus M, Polette A. Criteria for surgery in degenerative lumbar disc disease[ J]. Rev Chir Orthop, 1998,84: 583-589.
  • 8Lang P, Chafetz n, Genant H K, et al. Lumbar spinal fusion : Assessment of functional stability with magnetic resonance imaging [ J ]. Spine, 1990( 6), 15:581-588.
  • 9Toyone T, Takahashi K, Kitahara H, et al. Vertebral bone marrow changes in degenerative lumbar disc disease. A MRI study of 74 patients with low back pain [ J]. J Bone Joint Surg( Br), 1994,76(5) :757-764.
  • 10Ariga K, Miyamoto S, Nakase T, et al. The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc [ J ]. Spine, 2001,26 ( 22 ) : 2414- 2420.

二级参考文献7

  • 1龙厚清,刘少喻,李佛保.腰椎间盘退变/突出的分期及其病理学[J].脊柱外科杂志,2004,2(4):234-236. 被引量:10
  • 2Weishaupt D, Zanetti M, Hodler J, et al. Painful lumbar disc derangement: relevance of endplate abnormality at MR imaging. Radiology, 2001, 218:420.
  • 3Modic MT, Masaryk TJ, Ross JS, et al. Magnetic resonance imaging of the spine. Chicago, Yearbook Medical publishers, 1989, 280.
  • 4Fairbank J, Pynsent P. The oswestry disability index. Spine,2000, 25:2940.
  • 5Horton WC, Daftari TK. Which disc as visualized by magnetic resonance imaging is actually a source of pain? Spine, 1992, 17: 164.
  • 6Saifuddin A, Braithwaite I, White J, et al. The value of lumbar spine magnetic resonance imaging in the demonstration of anular tears.Spine, 1998, 23 (4): 453.
  • 7Chung CB, Vande Berg BC, Tavernier T, et al. End plate marrow changes in the asyptomatic lumbosacral spine: frenquency, distribution and correlation with age and degenerative changes. Skeletal Radiol, 2004, 33:399.

共引文献19

同被引文献110

引证文献8

二级引证文献41

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部