摘要
目的探讨单用和联用盐酸氨基葡萄糖与非甾体抗炎药(NSAID)在椎间盘源性腰痛(DLBP)治疗中的有效性。方法 2011年1月-12月72例DLBP患者,男42例,女30例;年龄22～71岁;体重43～84 kg;病程0.5～10年。通过随机数字表的方法,将患者分为3组。A组给予盐酸氨基葡萄糖胶囊750 mg,2次/d,同时给予尼美舒利分散片100 mg,2次/d;B组给予盐酸氨基葡萄糖胶囊750 mg,2次/d;C组给予尼美舒利分散片100 mg,2次/d。3组均用药8周后停药,用药期间停用其他活血化瘀类药物及物理治疗。选取治疗前及治疗后第4、8、16周4个时间点,运用疼痛数字评价量表(NRS)、Oswestry功能障碍指数(ODI)、生活质量评价量表SF-36分别对3组患者的腰痛、腰部功能及生活质量进行评价。结果 63例获得随访,失访率12.5%。各组患者NRS评分、ODI评分、SF-36评分在治疗前后比较差异均有统计学意义(P<0.05),A组疗效明显优于B、C两组,B组治疗后各项数据较治疗前明显改善(P<0.05)。结论单用盐酸氨基葡萄糖治疗DLBP有效,且在停药后,仍有一定疗效,联用NSAID效果更佳;远期疗效有待进一步随访。
Objective To investigate the curative effect of glucosamine hydrochloride or by glucosamine hydrochloride combined with non-steroid anti-inflammatory drug on discogenic low back pain（DLBP）.Methods Between January and December 2011,72 patients with DLBP（42 males and 30 females,22-71 years old,43-48 kg,disease course 0.5-10 years） were selected.They were randomly divided into group A,B,and C.Group A： 750 mg glucosamine hydrochloride combined with 100 mg Nimesulide Shulgin dispersible tablets,twice per day;group B： 750 mg glucosamine hydrochloride,twice per day;group C： 100 mg Nimesulide Shulgin dispersible tablets,twice per day.The treatment lasted for 8 weeks,and during this course,we stopped using Chinese medicines for promoting blood flow and eliminating blood stasis and physical therapy.The time of T1（before the therapy） T2（4 weeks） T3（8 weeks） and T4（4 weeks after the therapy） were chosen to evaluate the pain/function/quality of life by numerical rating scale,Oswestry Disability Index and short form 36 questionnaire.Results A total of 63 patients were followed up,the dropout rate was 12.5%,and there was significantly difference of the scores of NRS/ODI and SF-36（P0.05）.The curative effect in group A was better than that in group B and C.Conclusion Glucosamine hydrochloride is effective on DLBP even after the discontinuation,and its curative effect is better than that of glucosamine hydrochloride combined with non-steroid anti-inflammatory drug.
出处
《华西医学》
CAS
2012年第12期1818-1821,共4页
West China Medical Journal
关键词
盐酸氨基葡萄糖
椎间盘源性腰痛
非甾体抗炎药
Glucosamine hydrochloride
Discogenic low back pain
Non-steroid anti-inflammatory drug
