期刊文献+

生物起搏器的研究进展和展望

Study of Cardiac Biological Pacemaker and Its Future
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摘要 心脏生物起搏器是近年来心脏起搏的研究热点,目前主要集中在三大治疗策略;(1)细胞治疗;(2)基因治疗;(3)激素治疗。心脏生物起搏器处于研究初步阶段,应用于临床面临许多问题,但是随着分子生物学和基因工程技术的发展,心脏生物起搏器必将造福于人类。 The cardiac biological pacemaker is the focus of cardiac pace making in recent years. The search for such a pacemaker has centered on three therapy strategies : ( 1 ) cell therapy ; ( 2 ) gene therapy ; ( 3 ) hormone therapy. But the cardiac biological pacemaker is still in the phase of pilot study,and the application still face many problems. With the development of the molecular biology and genetic engineering, the cardiac biological pacemaker will benefit to the people.
出处 《心血管病学进展》 CAS 2008年第B05期4-7,共4页 Advances in Cardiovascular Diseases
关键词 生物起搏 细胞治疗 基因治疗 biological pacemaker cell therapy gene therapy
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参考文献27

  • 1Vesty J, Rasmusson KD, Hall J, et al. Cardiac resynchronization therapy and automatic implantable cardiac defibrillators in the treatment of heart failure:a review article[J]. J Am Acad Nurse Pract,2004,16(10) :441-450.
  • 2Proclemer A, Ghidina M, Cicuttini G, et al. The Italian lmplantable Cardioverter- Defibrillator Registry. A survey of the national activity during the years 2001- 2003[J]. Ital Heart J,2005,6(3) :272-280.
  • 3da Costa A, Kirkorian G, Cucherat M, et al. Antibiotic prophylaxis for permanent pacemaker implantation ; a meta-analysis [ J ]. Circulation, 1998,97 ( 18 ) : 1796 - 1801.
  • 4Rosen MR, Brink PR, Cohen IS, et al. Genes, stem cells and biological pacemakers[ J]. Cardiovasc Res,2004,64( 1 ) : 12-23.
  • 5Zalesskii VN, Dynnik OB. Molecular medicine;proteomic diagnostic technology and methods of molecular therapy in arrhythmology [ J ]. Lik Sprava, 2005, ( 1- 2) :3-10.
  • 6徐兆龙,刘仁光.心脏生物起搏的研究进展[J].国际心血管病杂志,2007,34(2):83-85. 被引量:3
  • 7Kehat I, Khimovich L, Caspi O, et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells [ J ]. Nat Biotechnol, 2004, 22(10) : 1282-1289.
  • 8Caplan AI, Bruder SP. Mesenchymal stem cells; building blocks for molecular medicine in the 21 st century[ J]. Trends Mol Med ,2001,7 (6) :259-264.
  • 9Plomikov AN, Shlapakova I, Szabolcs M J, et al. Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart [ J ]. Circulation, 2007,116 ( 7 ) : 706-713.
  • 10Huebach JF, Graf EM, keutheuser J, et al. Electrophysiological properties of human mesenchymal stem cells [ J ]. J Physiol,2004,554 ( Pt 3 ) :659 -672.

二级参考文献76

  • 1王方正,张奎俊,方丕华,马坚,楚建民,华伟,田瑞国,陈柯萍,鲁志民,朱克平,孙瑞龙,陈新.射频消融治疗不适当的窦性心动过速一例[J].中华心律失常学杂志,1997,1(2):117-121. 被引量:9
  • 2蔡军,林国生,江洪,杨波,蒋学俊,王腾,余奇劲.心肌细胞移植构建生物起搏器治疗缓慢型心律失常[J].中华实验外科杂志,2005,22(7):885-885. 被引量:2
  • 3李继文,郭继鸿,张萍,李春,刘元伟,周春燕.起搏通道基因亚型HCN4重组腺病毒载体的构建及通道电流检测[J].中国心脏起搏与心电生理杂志,2006,20(1):58-62. 被引量:17
  • 4[1]Edelberg J M,Aird W C,Rosenberg R D.Enhancement of murine cardiac chronotropy by the molecular transfer of the humanβ2-adrenergic receptor cDNA[J].J Clin Invest,1998,101(2):337-343.
  • 5[2]Edelberg JM,Huang DT,Josephson M E,et al.Molecular enhancement of porcine cardiac chronotropy[J].Heart,2001,86(5):559-562.
  • 6[3]Miake J,Marban E,Nuss HB.Gene therapy:biological pacemaker created by gene transfer[J].Nature,2002,419(6903):132-133.
  • 7[4]Miake J,Marban E,Nuss HB.Functional role of inward rectifier current in heart probed by Kir2.1 over expression and dominant negative suppression[J].Clin Invest,2003,111(10):1529-1536.
  • 8[5]Miake J,Nuss HB.Multiple ionic conductances sustain IK1 suppressed biopacemaking[J].Circulation,2003,108 (suppl 17):Ⅳ-35.
  • 9[6]Silva J,Rudy Y.Mechanism of pacemaking in IK1down regulated myocytes[J] Circ Res,2003,92(3):261-263.
  • 10[7]Qu J,Barbuti A,Protas L,et al.HCN2 over-expression in newborn and adult ventricular myocytes:diatinct effects on gating and excitability[J].Circ Res,2001,89(1):E8-E14.

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