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内质网应激与神经元退行性变 被引量：9

ER stress involves in neuronal degeneration
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摘要 内质网(endoplasmic reticulum,ER)是蛋白质修饰、折叠和钙贮存的场所。ER内未折叠或错折叠蛋白积聚和钙平衡失调均可导致ER应激。早期的ER应激或未折叠蛋白反应,是一种自身代偿过程,对细胞起到保护作用,而长期、严重的ER应激则会诱导细胞凋亡及死亡。研究发现,ER应激在许多神经退行性疾病的病理机制中起重要作用。然而,确切的机制目前仍不清楚。该文就ER应激在神经元退行性变中的作用作一综述。 Endoplasmic reticulum（ER） is a locus where proteins are modified,folded and calcium stored. The accumulation of un- folded protein and disorder of calcium ion can lead to ER stress. Early ER stress will induce unfolded protein response （UPR） which may be protective to cells. On the contrary, long-time strong ER stress will induce cell apoptosis, even death. ER stress has been suggested to be involved in some human neurodegenerative diseases. However, the exact contributions of ER stress in the various disease processes are yet unknown. This review mainly summarizes recently reported discoveries concerning ER stress associated with neurodegenerative diseases and highlights current knowledge in this field that may reveal novel insight into disease mechanisms and help to design better therapies for these disorders.
作者 冯利杰 王海萍 沈玉先
机构地区 安徽医科大学临床药理研究所 安徽医科大学神经生物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2007年第4期428-432,共5页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30572219) 教育部新世纪优秀人才支持计划资助项目(NoNCET-04-0589)
关键词 内质网应激 神经退行性疾病 未折叠蛋白反应 细胞凋亡 endoplasmic reticulum stress neurodegenerative disease unfolded protein response apoptosis
分类号 R-05 [医药卫生] R329.24 [医药卫生—人体解剖和组织胚胎学]
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参考文献33

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二级参考文献25

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共引文献8

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引证文献9

二级引证文献86

中国药理学通报
2007年 第4期

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