摘要
中药知母主要含皂苷,皂苷和皂苷元均是其主要活性成分。现代药理研究认为,知母及其有效成分能明显提高拟痴呆动物的学习记忆能力,改善脑功能衰退。该作用与其上调模型动物脑组织中胆碱能M受体、N受体,增强胆碱乙酰转移酶(choline acetyltransferase,ChAT)、抑制乙酰胆碱酯酶(acetylcholinesterase,AChE)活性,调节β受体-环磷酸腺苷(cyclic adenosine monophosphate,cAMP)、M受体-环磷酸鸟苷(cyclic guanosine monophosphate,cGMP)两系统间的平衡,以及改善脑内自由基代谢等方面相关。
Saponin and sapogenin are main components in chi- nese medicine Anemarrhena asphodeloides Bge. Modern research has shown that Anemarrhena asphodeloides Bge and its effective components could markedly enhance the ability of learning and memory in dementia animals, as well as improve the descent of brain function. The effect was related with many factors such as inhancing the cholinergic receptor （ M, N）, improving the activity of ChAT and inhibiting the activity of ACHE, regulating the balance of β receptor-cAMP and M receptor- cGMP, improving the metabolite of free radicals in model animal brains and so on.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第5期576-579,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30070931)
安徽省自然科学基金资助项目(No070413122)
安徽理工大学硕博基金资助项目(No2004YB41)
关键词
知母
有效成分
胆碱能系统
脑功能
anemarrhena asphodeloides
effective components
cholinergic system
brain function
