摘要
目的观察青春期甲状腺肿病人甲状腺功能的变化，研究其转归情况。方法收集2003-2007年吉林市中心医院内分泌科收治的青春期甲状腺肿病人51例，年龄11-18岁，其中男18例，女33例，根据最终的甲状腺功能分为3个组，A组单纯甲状腺肿组31例，B组甲亢组6例，c组甲减组14例。分别在首诊时，6个月后，及1-2年后测血清FT3、FT4、TSH、TPO-Ab、TG-Ab观察在三个阶段的数值变化，同时设26例健康对照组。结果在开始诊断青春期甲状腺肿的患者血清FT3、FT4、TSH、TPO-Ab均在正常范围。甲亢组6例，1年后，出现FT3、FT4增高，TSH降低，TG-Ab、TPO-Ab在半年后出现阳性。甲低组14例，1年后发展为临床甲减，但其半年时已出现TPO-Ab、TG-Ab阳性。31例单纯性甲状腺肿组，半年及1年后随诊，20例甲状腺肿大消失，11例甲状腺为I°－Ⅱ°，FT3、FT4、TSH、TPO-Ab均在正常范围。结论甲状腺肿作为甲状腺疾病的首发症状，早期各种检验结果均在正常范围，部分病人可发展为自身免疫病性甲状腺疾病，有时，甲状腺过氧化物酶抗体及球蛋白抗体可在早期存在相应的变化。
Objective To study the behavior of FT3 、FT4 、TSH, thyroid peroxidase antibodies and thyroglobulin antibodies in simple goiter of youth. Methods Correct 51 cases of the simple goiter of youth about 11 to 18 years old. According to their last thyroid foundation, the patients were divided into three grous： simple goiter group, hyperthyroid group, hypothyroid group. The levels of TPO - Ab TG - Ab as well as thyroid relevant hormones were measured three times. About the first, the second（ after six months） , the third （ after one or two years）. Results In simple goiter group, three times＇ measures were in normal range, just as the healthy subject, （ P 〉 0.05）. In hyperthyroid group, the second measure FT3, FT4, TSH were normal, the positive rate of TPO and TG - Ab were increased, the third measure FT3, FT4 were increasd and TSH was decreasd. The level of TPO - Ab, TG - Ab was increased. In hopothyroid group, the result was opposite to hyperthyroid of level of FT3, FT4, TSH, and the changes of TPO - Ab. TG - Ab were similar. Conclusion Simple goiter is the first and obvious symptom, although each laboratory test was in normal range. But some of the patients may become autoimmune thyroid disease. Sometime in the early times the level of TPO - Ab and TG - Ab were increased in the early stage.
出处
《中国地方病防治》
北大核心
2008年第3期228-229,共2页
Chinese Journal of Control of Endemic Diseases
