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胰高糖素样肽-1及其类似物和二肽酰肽酶-IV抑制剂对胰岛功能的保护作用 被引量：2

Protective effects of glucagon-like polypeptide 1(GLP-1),GLP-1 mimetics and dipeptidyl peptidase IV on pancreatic function
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摘要 胰岛β细胞功能受损是2型糖尿病发病的中心环节。随着病程的进展,多种机制参与导致β细胞功能进行性下降。胰高糖素样肽-1(GLP-1)是由肠道内分泌细胞L细胞分泌的肠促胰岛素,可以葡萄糖依赖性地增加胰岛素分泌、促进胰岛β细胞再生并抑制胰高糖素分泌。长效GLP-1类似物和二肽酰肽酶(DPP)-IV抑制剂能够减少内源性GLP-1在体内降解,从而更有效地保护胰岛β细胞功能,对于糖尿病的防治具有重要意义。 Impaired function of islet 13 cells is the center link in the onset of type 2 diabetes mellitus. Islet β cell function was impaired along with the progress of diabetes through variouse mechanisms. Glucagon-like peptide 1 （ GLP-1 ） is a kind of incretin secreted by intestinal endocrine L cells. It may increase the secretion of insulin, improve the neogenesis of islet β cells and inhibit the glucagons secreting. Long effective GLP-1 mimetics and dipeptidyl peptidase （DPP） - IV inhibitors may avoid the quick degradation and inactivity in vivo like GLP-1 and protect islet β cells function more effectively. It＇ s meaningful in prevention and cure of diabetes mellitus.
作者 唐伟 徐宽枫 刘超
机构地区 南京医科大学附属第一医院内分泌科
出处 《国际内科学杂志》 CAS 2008年第5期269-273,共5页 International Journal of Internal Medicine
关键词 2型糖尿病 胰岛功能 胰高糖素样肽-1 二肽酰肽酶-IV抑制剂 Type 2 diabetes Pancreatic function Glucagon-like peptide 1 Dipeptidyl peptidase-IV inhibitor
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献21

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二级参考文献4

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共引文献12

同被引文献16

  • 1孙圣斌,侯晓华.GLP-1在摄食和胃肠道生理功能中的作用[J].胃肠病学和肝病学杂志,2005,14(2):212-214. 被引量：5
  • 2董凌燕,刘超,张梅,刘翠萍,覃又文.胰升糖素样肽-1对胰岛β细胞胰岛素基因表达的调节作用[J].江苏医药,2006,32(1):45-46. 被引量：2
  • 3崔岱,刘超,唐伟,蒋琳,朱剑,刘翠萍.GLP-1对大鼠胰岛细胞增殖及凋亡的影响[J].中国糖尿病杂志,2007,15(5):310-312. 被引量：13
  • 4傅勇,李蓬秋.GLP-1抗糖尿病作用研究进展[J].实用糖尿病杂志,2007,3(3):53-55. 被引量：8
  • 5徐宽枫,刘超.胰高血糖素样肽1相关研究的进展[J].江苏医药,2007,33(7):728-730. 被引量：2
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  • 8Li L, El-Kholy W, Rhodes CJ, et al. Gtucagon like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B [J]. Diabetologia, 2005,48 ( 7 ) : 1339-1349.
  • 9Bulotta A, Hui H,Anastasi E, et al. Cultured pancreatic ductal cells undergo cell cycle redistribution and beta-cell-like differentiation in response to glucagon-like peptide-1 [J]. J Mol Endocrinol, 2002,29 (3) : 347-360.
  • 10Green BD, Gault VA, Mooney MH, et al. Novel dipeptidyl peptidase Ⅳ resistant analogues of glucagon-like peptide-1 (7- 36) amide have preserved biological activities in vitro conferring improved glueose-lowering action in vivo[J]. Journal of Molecular Endocrinology, 2003,31 (3) : 529-540.

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国际内科学杂志
2008年 第5期

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