摘要
目的观察一种集化疗和内照射于一体的新型“双弹头”免疫导向治疗肝癌的效果。方法以大鼠抗人甲胎蛋白（ＡＦＰ）单克隆抗体（抗ＡＦＰＭｃＡｂ）和马抗人ＡＦＰ多克隆抗体（抗ＡＦＰＡｂ）为载体，１３１碘（１３１Ｉ）或１２５碘（１２５Ｉ）和丝裂霉素（ＭＭＣ）为“双弹头”，用改良氯胺Ｔ法制备１３１Ｉ－抗ＡＦＰＭｃＡｂ－ＭＭＣ（双弹头Ｉ）和１３１Ｉ（或１２５Ｉ）－抗ＡＦ－ＰＡｂ－ＭＭＣ（双弹头Ⅱ），治疗中晚期肝癌４１例（治疗组）。治疗１、２、３次分别有４、２４和１３例，放射剂量（ＭＢｑ／例）依次为１９８．３２±３７．８６，６５１．９±２０２．４和９９８．０±２２０．５。结果治疗后肿瘤缩小率，血清ＡＦＰ下降率和１、２年生存率分别高于同期经动脉灌注（ＴＡＩ）或化疗栓塞（ＴＡＣＥ）的对照组［５７．５％（２３／４０）比３２．５％（１３／４０），Ｐ＜０．０１；６５．７％（２３／３５）比３７．５％（１２／３２），Ｐ＜０．０１；５８．５％比３７．５％，４５．０％比１９．０％，Ｐ＜０．０５］，治疗组病例的进展率（９．８％）明显低于对照组（３５．０％，Ｐ＜０．０１）。结论“双弹头”疗效的提高可能是由于抗体、核素和抗癌药的协同作用而增强了对癌细?
PURPOSE To observe the effect of a “double bomb” with the merit of chemotherapy and internal radiotherapy on immunotargeting therapy for primary liver cancer. METHODS Murine anti human AFP monoclonal anti body(anti AFPMcAb)and horse anti human AFP polyclonal antibody(anti AFP Ab)as carriers, and nuclide 131 I or 125 I and mitomycin C(MMC) as warheads were used to prepare “double bomb Ⅰ” consisted of 131 I antiAFP McAb MMC and “double bomb Ⅱ” consisted of 131 antiAFP Ab MMC. Such“double bomb” targeting therapy was used to treat 41 cases of unresectable primary liver cancer by intravenous drip or hepatic artery infusion (treatment group). Among them 4,24 and 13 cases were treated 1,2 and 3 times respectively, and the median values of the radiation dose(MBq/case) were 198.32±45.50,651.9±202.4 and 997.85±220.0 respectively. RESULTS The shrinkage rate of tumor, decreases level of AFP and the 1,2 years survival rates were significantly higher than those of the control group with transarterial infusion (TAI) or transarterial chemoembolization (TACE) at the same time(57.5%, 23/40 vs 32.5%, 13/40, P <0.01; 65.7%, 23/35 vs 37.5%, 12/32, P <0 01 and 58.5% vs 38.0%, 45.0% vs 19.0%, P <0.05,respectively). Furthermore, the tumor progression rate (9 8%)in the treatment group was significantly lower than that of the control group (35.0%), P <0.01. CONCLUSIONS “Double bomb” targetherapy is better due to the synergism effects of the antibody, radiosiotope and anti cancer agents, and thus enhancing the tumor killing effect for tumor cells.
出处
《中国癌症杂志》
CAS
CSCD
1997年第3期184-188,共5页
China Oncology
基金
国家"八五"科技攻关基金
关键词
肝肿瘤
放射免疫疗法
碘131
liver neoplasms
radioimmunotherapy
iodine radioisotopes
antibodies,anti alpha fetoproteins
mitomycin
