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糖尿病对血脑屏障影响的研究进展 被引量：4

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摘要 糖尿病可以导致血脑屏障形态学改变、屏障功能及转运功能发生变化。基膜增厚是形态学中特征性的改变;屏障功能的破坏导致血脑屏障对小分子物质的通透性增加,其好发于大脑的某些特定区域如中脑等;转运功能的改变导致血脑屏障对葡萄糖、胆碱、胰岛素等重要物质的转运发生改变。其机制与大脑微循环血流动力学改变、微血管生化性质改变及毛细血管神经递质活性变化有关。本文就上述内容的研究进展进行综述。
作者 余爱勇 赵玉武
机构地区 上海交通大学附属第六人民医院神经内科
出处 《国际神经病学神经外科学杂志》 2008年第2期150-153,共4页 Journal of International Neurology and Neurosurgery
基金 上海市自然科学基金(07ZR14059)
关键词 糖尿病中枢神经系统并发症 血脑屏障 高血糖
分类号 R587.1 [医药卫生—内分泌]
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共引文献7

同被引文献21

  • 1范瑞明,余昌胤,杨丽,詹剑.糖尿病大鼠缺血-再灌注对脑组织核转录因子-κBp65和基质金属蛋白酶-9表达的影响[J].中国现代神经疾病杂志,2007,7(1):61-65. 被引量：2
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国际神经病学神经外科学杂志
2008年 第2期

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