摘要
目的研究2006年山西省运城市成人流行性乙型脑炎的临床及实验室检验特点，为我国乙脑预防控制提供基础资料。方法对2006年运城市第二人民医院收治的45例乙脑病例进行临床资料分析，对部分中老年患者血清和脑脊液标本进行血清学和分子生物学检测。结果收治入院的45例患者以中老年人为主，其中40岁以上病例占病例总数77．8％（35／45），重型和极重型占病例总数60．0％（27／45），大多数患者合并基础性疾病。研究结果显示，血清乙脑病毒IgM抗体检测为阳性，急性期和恢复期双份血清中和抗体存在4倍以上增高；部分患者脑脊液乙脑病毒核酸检测阳性。结论经实验室特异性检测确认山西省运城市2006年病毒性脑炎为乙型脑炎，病例呈现大年龄组发病特点。
Objective To study the clinical and laboratory characteristics of adult Japanese encephalitis （JE） patiens in a JE outbreak in Yuncheng, Shanxi province in 2006. Methods All the clinical data from the Second People＇s Hospital in Yuncheng city were analyzed, part of patients＇ sera and cerebrospinal fluid were tested by serology and RT-PCR. Results The majority of patients were middle-aged and elderly, 77.8 % （35/45）of the total eases were more than 40 years old. Severe and fulminating type cases accounted for 60.0% （27/45）. Most patients had underlying diseases. IgM antibody to JE virus （JEV） in serum was positive in each of the 45 patients analyzed and 4-fold or greater rise in sera neutralization antibody titer were found in convalescent serum. JEV nucleic acid was positive in part of cerebrospinal fluid specimens. Conclusion Viral encephalitis emerged in Yuneheng city, Shanxi province was Japanese encephalitis B, and most of the cases belonged to elderly group.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2008年第2期95-97,共3页
Chinese Journal of Experimental and Clinical Virology
基金
基金项目：中日传染病项目资助（Japanese Science and Health Foundation）
关键词
脑炎病毒
日本
IGM抗体
中和试验
Encephalitis virus, Japanese
IgM antibody
Neutralization tests
